Like "I became diabetic when I was 11 months old, so understand the feeling of being the "odd guy", especially since my school was small (45 in my class) and EVERYONE knew what i had. That was actually a good thing! But it doesn't make the child feel much better. There is no quick fix for this. But you can help them keep things in perspective. If you have a good speaking relationship with them (I have a 5 year old, he can be challenging!), find a quiet time to ask them if they have friends who are challenged by classes in school or physical activities, and then point out that those are things your boys have a handle on that the other kids have to work hard on too. Do a study of medical conditions people have that seem so obvious to them but you would never notice if you weren't told. And the bigger questions, are there kids in school with physical disabilities and how do your boys feel about them? If it's not good, challenge them to understand why everyone has to be appreciated for who they are and what they can do. None of this is lightweight stuff! But their developing feelings about themselves and their place in the world is a long term thing. The more you can delve into how they feel and keep those feelings in perspective will let them fly as they grow. I don't think I EVER had anyone make fun of me, but back then it was one injection a day (at home) and no blood testing. So my only obvious problems were passing out in class occasionally from not enough to eat. Kids are remarkable, if there is respect in the classroom, they just never bring it up again and it's forgotten! Hopefully they have a great school environment that will help you work them through this uncomfortable stage!"