Why do I get so irritated and what can I do to stop it or at least not be irritated so often? I was diagnosed with diabetes almost three years ago with an A1c of 7.5. It is now at 5.7 and has been for over a year now. I take 500mg Metformin four times a day and my BG averages around 105. My only real problem seems to be the irritability; I can feel it coming on and can tamp it down most of the time.