i recently started taking simvastatin and it says not to eat grapefruit. Does this apply to oranges and lemons too?

Dr. William Sullivan


Grapefruit juice inhibits an enzyme that enables the body to metabolize several of the statin medications, including simvastatin. This enzyme inhibition is unique to grapefruit juice and does not happen with lemons or oranges. Drinking grapefruit juice can increase the level of simvastatin in the blood and possibly increase the risk of muscle side effects caused by simvastatin. This effect of grapefruit juice occurs only with large quantities of grapefruit juice. Drinking less than 8 oz. of grapefruit juice or eating less than ½ of a grapefruit is unlikely to have a significant effect. You should be sure and discuss this further, as well as other drug interactions with simvastatin, with your healthcare provider.

January 9, 2012 at 7:52 pm