Is there any reason why your glucose levels actually rise (significantly) with diabetes medications? This has been my experience with metformin, glimepiride/glipizide, and onglyza.

Dr. William Sullivan


The medications that you mention are common medications used to treat type 2 diabetes. Metformin is the most common initial medication used for type 2 diabetes, and will lower blood glucose levels by decreasing the amount of glucose secreted by the liver. Both glimepiride and glipizide are sulfonylureas that stimulate the pancreas to secrete more insulin. Onglyza is a newer medication in the class of oral diabetes medicines called DPP-4 inhibitors. This class both stimulates more insulin secretion from the pancreas and lowers glucose secreted by the liver. People with diabetes may have different responses to the various medications that are used to treat type 2 diabetes. The majority of people will have improvement in blood glucose levels. As with all medications, there are some people who are non-responders and do not have a significant lowering of blood glucose levels. There are many reasons for elevated blood glucose levels, but these medications are not associated with causing an increase in blood glucose levels. You should review with your healthcare provider the possible reasons why your blood glucose levels might be increasing.