I have been avoiding taking Metformin for years. My A1C has been between 6.0 and 7.4 for the last 6 years. I have been managing it with constantly improving diet and exercise. I have hepatitis C and was told by a doctor that Metformin was one of the worst things for the liver. Is that true?

Dr. William Sullivan


Metformin is considered the first line medication for the treatment of type 2 diabetes. It is effective at lowering glucose levels without hypoglycemia or weight gain. Although very effective, metformin is contraindicated if significant liver or kidney disease is present. Metformin does not adversely affect liver function, but should not be used if there is significant underlying liver disease. Hepatitis C can cause variable liver dysfunction. If liver disease is only mild, metformin can still be considered. You should discuss the degree of your liver disease with your healthcare provider and whether you would be a candidate for metformin to help control your blood glucose levels.

1 reply

MyMamakat 2012-07-29 18:14:34 -0500 Report

Hello Dr. I too am a diabetic with the added challange of having HepC from a blood transfusion in 1982.Mostly I am in good health,but my Dr.wants me to get my A1c lower than the 7 it is now.I am VERY interested in treatment to blow the HepC out of me.I have gone from nearly 400lbs 10 yrs ago.before I knew I have the disease,to 195 now.My goal is 175,but I just cannot seem to lose that last 20lbs.My Dr. is internal med,is he being a little too strict about the A1c?I am 60 yrs old,would I be considered as a good candidate for Interferon/Ribavarin+ treatment that is available now.Any feedback would help my decisions in the future.Thankyou Doctor.Kathleen Dunham,Needles Ca.