Do you have any idea why my medication isn't lowering my blood glucose numbers? I'm taking Janumet 50/500 and have yet to have a BG lower than 151.

Dr. William Sullivan


Janumet is a combination medication containing Januvia (sitagliptin) and metformin. Januvia is one of the newer medications in the class called DPP-IV inhibitors and metformin is an older medication in the class called the biguanides(the only other biguanide was phenformin which is no longer on the market). These 2 medications (Januvia plus mmetformin) when combined can be complementary with different mechanisms of action. An advantage is that neither medication is associated with weight gain or low blood glucose levels. However, in some cases, this combination of these medications may not be sufficient to lower blood glucose levels to within goal. You should review your medications with your healthcare provider. As always, diet and exercise play a primary role in the treatment of type 2 diabetes.