What other ways can circulating blood sugar be better controlled besides increasing Metformin dosage? Is it harmful to keep increasing the dosage (was 500 x 2/day, now 1000 x 2/day)? Thank you. Roxane

Patty Bonsignore


Blood glucose can be improved by controlling the amount of carbohydrate you eat at meals and by increasing physical activity. For women, we recommend, on average, 30 to 45 grams of carbs per meal; for men we recommend 45 to 60 grams of carb per meal, but this can vary depending on the individual. For physical activity, we recommend 30 minutes per day at least 5 days per week. If you are doing all these interventions already and your blood glucose is still high, it makes sense to take medicine. There is no harm in taking the highest dose of metformin . Metformin has been used for many years and has one of the best safety profiles of any diabetes medication available. In fact, metformin is so safe that it has been studied for use in pregnancy. 1000 mg twice a day is the most common dose. We do not recommend using metformin if you have kidney problems, if the metformin causes significant stomach upset, or if you have a history of binge drinking. If none of these conditions apply, there is no reason for you to worry about taking metformin at its highest dose if that is what your doctor prescribes.

February 3, 2014 at 10:58 am