This morning my blood sugar was 87 — down 100 points in 3 weeks. Besides eating healthier I am drinking apple cider vinegar and taking, as a supplement, isohumolone. Would you tell me if this is a safe supplement and is it effective? As I said, I lost 100 points (average) in three weeks whereas before I could not get below 150 just by eating healthy.

Dr. David Erani


Isohumulones are found in hops, a main ingredient of beer. They have been shown to activate the same receptor as thiazolidinediones (Actos and Avandia) a class of anti-hyperglycemic medications. In 2009, researchers from Kirin, a Japanese beer company, published a paper describing the effects of isohumulones on people with prediabetes. In their study, those treated with isohumulone had lower fasting blood glucose, A1C, and body weight compared to those treated with a placebo. Each of these differences was statistically significant – not likely due to chance. While statistically significant, the differences were all small in magnitude. For example, after 12 weeks of treatment, fasting blood glucose was decreased by 6.7 mg/dL and A1C was decreased by 0.29% in the group receiving the highest dose of isohumulones. In this study, there were no adverse effects reported. Vinegar has also been reported to have a blood glucose-lowering effect, specifically decreasing insulin resistance and the rise in blood glucose after a meal. As is the case for isohumulones, the effect seems to be modest. So, it seems that both isohumulones and vinegar have some blood glucose-lowering effect and are safe in moderation. That said, they are not likely to account for the significant decrease in blood glucose that you have seen. You deserve more of the credit.

June 14, 2013 at 1:51 pm