What can I do to minimize GI upset? Within 2 hrs of taking metformin, I have terrible GI upset (gas, cramps, etc). After 2 or 3 days of this, I stop the metformin and the GI issues resolve. Then I restart the metformin and the cycle begins again. My PCP says to tough it out but this has been going on for almost a year. Also, my PCP keeps increasing my metformin dose (now @ 1000 MG/BID) to get my FBS lower. FBS avg = 130-140 a.m.

Patty Bonsignore


It’s important when starting metformin to take it on a full stomach and to increase the dose gradually. It may take up to four weeks to get to a 1000 mg twice a day. Ask your doctor how best to do this. Once you are on your maximum dose, it may take a week or two for the stomach upset to get better. If you stop the dose and restart it, make sure to go up on the dose slowly again; don’t start right back on a 1000 mg twice a day. If you have tried this already and it has not worked, then ask your doctor about using an extended release form of metformin. For some, this helps reduce stomach upset. You can also ask your doctor about Glumetza, a brand-name form of metformin. Glumetza is absorbed slightly differently than regular metformin and may help relieve your symptoms. If none of these suggestions help, than ask your doctor about going on a lower dose. If a lower dose does not help, then it may be that you simply can’t tolerate this drug. It is a common problem. Ask your doctor about other drugs you can try to help treat your diabetes.

April 7, 2013 at 10:18 am

2 replies

elmirerod1919 2014-09-20 14:00:37 -0500 Report

do you want a true answer? metformin, buformin, and phenformin are all poisons that are an excuse to keep down blood sugar in a person with type 2 which either by stomach stapling or thru starvation can be reversed, and in most it never returns even with the bad habits returning. I am a type 1 who was told i am positively a type 2 for six years and i took metformin which did nothing but give me gas and diahreeah and ended up killing all my beta cells, because come to find out, i was a type 1 misdiagnosed, to which metformin is a deadly poison. I would not touch a metformin until i took a c peptide test and if i was told i was a type 2 i'd suck it up and live on 600 calories a day for three months and it would be reversed. once you lose the fat around the pancreas the t2diabetes is gone. and i've tried it last winter. I was meticulous, and imagine my face when they tell me my a1c is 10.1. Now that right there should be enough to tell any doctor that the diabetes is most definitely type 1 but either it's a conspiracy to save a lot of money, as long as metformin works a while it's 40xcheaper than insulin. If you were a true type 2 metformin would NEVER stop working. the ones that "progress" to insulin are all LADA and type 1 who should had been started on insulin immediately, in any case. If you are a true type 2 and don't care, take the metformin, it will keep your sugar down. But you could so easily reverse the diabetes just by starving for three months. I know i did it so i know it can be done, just like quitting smoking, the day i was diagnosed diabetic i gave it up and never wanted another one it was 3 to 4 packs a day for me. Metformin i find is a very poor excuse for controlling diabetes when diet works so much better. You know in china if someone is type 2 diabetic they staple the stomach even if the person is thin the way it bypasses the pancreas cures the disease for type 2. They should do stomach stapling for 30bmi if you have t2 diabetes not 35

PeggySue1234 2013-11-09 13:57:27 -0600 Report

Is there any medication one could take to replace Glipizide ? I feel lower back and side pain , feel they r from the Glipizide.