Byetta and Symlin

By Germaine Latest Reply 2011-02-14 10:34:59 -0600
Started 2010-07-17 14:14:41 -0500

My friend told me his doctor gave him Byetta to help him loose weight and yes he's type 2 diabetic, but i am type 1 i wonder if it will work for me too.

My doc gave me Symlin to loose weight, but i have not tried it yet.
what do you think of those.

They cause nausea, so make u eat less, but i don't eat much already
so not sure why i gained

4 replies

kdroberts 2011-02-14 10:34:59 -0600 Report

There are studies about using Byetta and Victoza (same thing, different manufacturer) in type 1's and they show that they both help with weight loss and reduce insulin need. They don't do anything for insulin secretion in type 1's but they help keep the liver from releasing too much glucose as well as making you feel less hungry like Symlin but in a different way. It also helps slow down how fast food leaves your stomach so you feel fuller for longer. There's some talk about it helping reduce fat in the liver but I don't know too much about that.

The nausea is an unwanted side effect, it isn't how it really makes you eat less.

Hops 2011-02-14 08:28:34 -0600 Report

All diabetics are Amylin deficient. Diabetes Health has a great article about this. "Insulin's Partner: Amylin
Linda von Wartburg
Jan 28, 2011
Insulin has a companion, and it's called amylin. Amylin is a small hormone that is released along with insulin by the beta cells of the pancreas in response to a meal. When people are insulin-deficient, they are amylin-deficient as well. Amylin wasn't even discovered until 1970, and it was not until the 1990s that scientists began to figure out what amylin does. But they now know that it partners with insulin to help control blood sugar levels, each in its own way:

Insulin controls how much sugar gets out of your blood and into the muscles and tissues in your body. Without enough insulin, too much sugar remains in the blood

Amylin helps control how much sugar gets into your blood after a meal, and how quickly it gets there. Amylin keeps too much glucose from appearing in the blood in the first place.

Amylin accomplishes this in a number of ways. It decreases appetite by promoting a feeling of fullness, thereby reducing food intake. It slows gastric emptying and inhibits the secretion of digestive enzymes, all of which slow the appearance of glucose in the blood after a meal. It also inhibits the secretion of glucagon, which otherwise causes additional glucose release by the liver at mealtimes.

In short, the release of amylin minimizes the glucose spikes that often occur after meals in insulin-dependent diabetes. A smaller glucose spike means that less insulin is needed to manage post-meal glucose.

Symlin (pramlintide acetate) is a longer-acting analog, or form, of amylin that was created by Amylin Pharmaceuticals. The man-made form of amylin does all the good work that natural amylin does, decreasing the rate of gastric emptying, increasing satiety, lowering after-meal glucagon secretion, and controlling after-meal glucose spikes. People on Symlin tend to need less insulin for meals, and they also tend to lose weight. It was approved by the FDA in 2005 for injection by people with type 1 diabetes and insulin-using people with type 2

Amylin Pharmaceuticals, which manufactures Symlin, recently placed a microsite on the Resources section of (the online social network community of the Juvenile Diabetes Research Foundation).The microsite is intended to educate people with type 1 diabetes about the role that Symlin injection can play in diabetes management and provide an online forum for people to exchange stories and share personal insights about using Symlin. The Symlin microsite is available at"

Diane987 2010-07-18 11:38:35 -0500 Report

Hi Germaine,

Symlin and Byetta are actually two very different drugs. Symlin is man-made amylin, which the beta cells secrete with insulin. Symlin is used with type1 diabetics because there are no functional beta cells to stimulate.

Byetta is artificial GLP-1 (Glucagon Like Peptide-1) which is secreted by the digestive system in response to the physical filling of the stomach with food, and tells your beta-cells to release a little squirt of insulin to prepare for the food. It was discovered in Gila Monster saliva.

I take Byetta and I typically don't get nausea. Even when I first started the medication I was a little afraid of the side effects because I read horror stories about diarrhea, nausea and vomiting on the internet, but it didn't happen to me. The only time I get a little nausea is when I wait too long to eat after I have injected the medication. My instructions are to wait 1/2 hour to an hour after injecting to eat. Around 45 minutes is when I start feeling a little nausea, but it goes away as soon as I start eating.

I know I eat less on Byetta because it takes longer to digest food so I feel full longer than when I wasn't taking it. My brother says he doesn't eat much but the rest of the world would consider his "not much" enough food for a well fed family of four. I am wondering if your "not much" is similar to my brothers?

Good luck and God Bless,


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