For me, it would have to be "Have you taken your insulin?" after I have made the comment about having a "sugar crash". I end up having to fight the urge to scream "OF COURSE I'VE TAKEN MY INSULIN YOU IDIOT! WHY DO YOU THINK I'M HAVING A SUGAR CRASH?! GO TAKE BIOLOGY FOR CRYING OUT LOUD!", and I just go eat some bread or potatoes.
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