Bob, The Forecaster
By Bob, The Forecaster Latest Reply 2014-07-24 12:31:02 -0500
Started 2010-03-30 14:44:00 -0500

Does anyone have information about the auto-immune value and/or reversibility of LADA (latent auto-immune diabetes for adults) using LDN (low-dose naltrexone) as recommended by highly-regarded supernutritionist Julian Whitaker, MD?

LDN Boosts Immune Function
It would be several years before the mechanisms were understood, but we now know that when LDN is taken at bedtime, it binds to opioid receptors and temporarily blocks endorphins from attaching. This action signals the body to increase endorphin production, an effect that can last as long as 18 hours.

Opioid receptors aren’t exclusive to the brain. They’re also present on all types of immune cells,
including macrophages, natural killer cells, T- and B-cells, and even stem cells. As a result, the flood of endorphins set into motion by LDN stimulates the immune system and enhances the body’s ability to fight disease.

The benefits of this remarkable drug have been proven in a number of scientific studies, several of which were presented at the Fourth Annual LDN Conference recently held on the campus of the University of Southern California School of Medicine.
Low dose naltrexone (LDN)
Main article: Low dose naltrexone
Low dose naltrexone (LDN), where the drug is used in doses approximately one-tenth those used for drug/alcohol rehabilitation purposes, is being used by some as an "off-label" experimental treatment for certain immunologically-related disorders,[10] including HIV/AIDS,[11] multiple sclerosis[12] (in particular, the primary progressive variant,[13]) Parkinson's disease, cancer, fibromyalgia,[14] autoimmune diseases such as rheumatoid arthritis or ankylosing spondylitis, Crohn's disease, ulcerative colitis, Hashimoto's thyroiditis, and central nervous system disorders.

9 replies

sonhaslada 2014-07-24 12:31:02 -0500 Report

You won't hear much about using LDN for diabetes because there have been no studies. Usually diabetes progresses so quickly, there is nothing left to save. LADA is a much slower progression taking up to two years to destroy the beta cells. Dr. Bahiri had several patients with type one diabetes on LDN and none of them progressed to full insulin dependence. Dr. Zagon at Penn State University has done extensive research on LDN for Crohn's disease. He told me although there have been no studies to confirm it helps with Type One Diabetes, it would not hurt to try it. Well, it works!

sonhaslada 2014-07-24 12:22:31 -0500 Report

My son started LDN in the fall of 2011, a year after his diagnosis with LADA. He was positive for antibodies. He has not deteriorated since that time. He is 200 pounds and 26 years old. He takes 10 units of lantus a day and 10-16 units a day of additional insulin before meals. So his total amount is 20 to 16 units a day. From what I have read, that would officially put him into remission. I do not know very much about diabetes because he was diagnosed as an adult, but our cat has type two diabetes and gets two injections a day of 6 units Lantus each time. That means our 20 pound cat is getting more Lantus than our 200 pound son. My son's blood sugar is very well controlled and his A1c is normal. The cat always has high blood sugar, above 200. Anyone recently diagnosed with type one diabetes should try to preserve as much beta cell function as possible with LDN. It is completely safe. Yes it was originally intended for addiction but using at a fraction of the dose only blocks the opiate receptors for a few hours which triggers the body to produce massive amounts of endorphins. LDN helps the body produce 300% more REGULATORY T-Cells to call of immune attacks.

GabbyPA 2010-03-30 15:05:14 -0500 Report

What I have found is that patients diagnosed later in life with type 2 sometimes actually have LADA, which is actually a type 1 diabetes that initially responded well to oral treatments. This is a whole new realm of study for me, I was unaware that this type of diabetes was out there.

Here are some of the links I read on this subject: http://www.diabetesmonitor.com/lada.htm

My question is what do we ask our doctors to check to make sure we do not have LADA instead of type 2? If we do all we can and take our meds and still high numbers persist, could this be a symptom?

The LDN seems that it is more for use in addiction patients. It was approved by the FDA in 1984, but was used mostly for heroin addicts. I looked at the list of illnesses it is supposedly been tried on, but diabetes is not there. Right now, it is not approved for these uses. Check out this link to read more. http://www.lowdosenaltrexone.org/index.htm#What_is_low_dose_naltrexone
It sounds like it has a long way to go. The video in the above link does offer promise.

kdroberts 2010-03-30 15:19:58 -0500 Report

You would ask for the antibody tests that a type 1 would usually get flagged on, like GAD65/67. It's tough because it's not fully understood yet.

As for Julian Whitaker, I don't think he is highly regarded by many people other than himself. A salesman more than a doctor.

GabbyPA 2010-03-30 15:56:05 -0500 Report

Yes, I do have to agree with your Whitaker statement. I have seen a lot of him, but don't hear much about him if you know what I mean.

So if I ask for an antibody test? Is my regular clinic doc going to understand that? He won't do a B12 on me or a microalbumin test. I have asked for both and he says I don't need those.

kdroberts 2010-03-30 19:22:07 -0500 Report

If your doc wont give you a microalbumin then he sure as hell wont give you antibody testing. If you can get a c-peptide that would be a good start as it would show that you have low insulin production which would indicate that maybe that is where the problem is, not insulin resistance. The doctor should know what the tests to do are but getting them to write the script is another thing. Microalbumin is a very important test and is recommended for diabetics to have it done once a year so you may want to push harder to get it done.

Amy had a guest blog recently that had some excellent info about LADA (and kidneys), it would be worth reading.

You may also want to check out

and if you want to read up on MODY

GabbyPA 2010-03-31 12:55:06 -0500 Report

Thanks KD,
According to the information in these links, I am most likely not a candidate for LADA. I had heard about people saying they were type 1.5, but I did not understand what they meant. I do need to get more insistent with my doctor about my Microalbumin test though. Thank you for the links, they are great.