Synthetic Insulin Side Effects

Crashnot
By Crashnot Latest Reply 2011-09-07 13:49:52 -0500
Started 2010-03-08 17:14:07 -0600

I just posted this info on a post I made earlier today about not feeling well.

But after Googling "Synthetic Insulin Side Effects" I got an education and wanted to pass it along on a separate post.

This is nasty stuff and getting worse! As the patents run out on the original synthetic insulins, they are coming out with "analog" versions that are troublesome.

For those of you who have wondered about being MOODY, DEPRESSED, CONFUSED, have unexplained Aches and Pains, feel unwell for no reason, or LETHARGIC, please read this report and do your own Googling.

I am in the process of getting a vial of the pork insulin from the lab in the report. It is still being produced in the UK and is available in Canada and most likely the US. I hope to recover my energy and mental alertness just as quickly as I did when I quit using first Lantus and then Levemir.

Hopefully these problems do not affect you, but better to be aware than floating around like a zombie as I am.

I might be remembering wrong, since my mind has been mush for a few years (about as long as I've been using Humalog, actually), but I think it said the synthetic effects about 10% of users. That's a lot in my book!

Here is the best link I found:

http://www.iddt.org/wp-content/uploads/2009/1...
Lisa


20 replies

TSasabuchi
TSasabuchi 2011-09-07 13:49:52 -0500 Report

Most modern medicines have horrible side effects. just look at anti-depressents. Modern medicine is making us choose between our life and health…

rankearl
rankearl 2010-03-09 08:57:15 -0600 Report

lisa hi i found that report on the insulin dependent diabetes trust site wow it make me think i had every symptom i read the comments by other diabetics and said wow again i picked up on that they said natural insulins have antibodys that help with the process of lowering blood sugars slower closer to the normal action of insulin i would be willing to try this if i could still use my pump i will ask my dr when i go next thanks ((HUGS)) julie

Crashnot
Crashnot 2010-03-09 09:26:15 -0600 Report

Here's a good article that came out about the time the pork/beef insulins were discontinued. Very interesting, especially if you have children on insulin. Many doctors believe they do better on the animal-based products. Having been a child diabetic who used those products I would agree. I rarely had hypoglycemia events. They were a family event when I did, they were so rare. Now I have them a few times a week and fortunately am tolerant enough of them to treat myself.

http://www.diabeteshealth.com/read/1999/12/01...

Just a note, I'm pretty sure these don't work in the pump because they work for many hours, even the short term "R" type. But I will gladly go back to 2-3 injections a day if I can have my energy and stability back!

rankearl
rankearl 2010-03-09 10:33:55 -0600 Report

lisa i will look at that too you really have me thinking i have been a brittle diabetic all my life on both kinds of insulins i have had black outs and siezures both now and when i was younger i myself havelearned i am very sensitive to insulin when i was still working and had insurances i ate every 2hours and tested every 2 hours i still researching but my pump changed my life i did well with it until the last 2 years and i started having issues with pain im strechting my pump supplies and not testing as often as i should due to no insurance with all that i have ben through with diabetes i am very blessed that i am still alive all of us have people who love us soo we need to just to just keep doing what w need to do again thanks for the info im still researching ((HUGS)) julie

Crashnot
Crashnot 2010-03-09 11:05:14 -0600 Report

Julie, sounds like we're swimming for the same boat! I've been labeled "brittle" for years and am pretty unaware of when my sugars are dropping. I was told it's just because I've been diabetic for so long and my nerves have been damaged. But I have no feet, kidney or eye damage. Hmmm?

I have already gotten an email back from the Canadian company that distributes the porcine insulin and I can get it by special order from any pharmacy in Canada. The downpoint? Looks like it is about $125 a vial.

She is not sure if it is stable at body temp for the pump, and will let me know when she is back in the office next week. I will let you know! I'm half hoping it's not suitable for the pump. As convenient as it is, it's a hassle too!

Crashnot
Crashnot 2010-03-09 11:05:45 -0600 Report

Julie, sounds like we're swimming for the same boat! I've been labeled "brittle" for years and am pretty unaware of when my sugars are dropping. I was told it's just because I've been diabetic for so long and my nerves have been damaged. But I have no feet, kidney or eye damage. Hmmm?

I have already gotten an email back from the Canadian company that distributes the porcine insulin and I can get it by special order from any pharmacy in Canada. The downpoint? Looks like it is about $125 a vial.

She is not sure if it is stable at body temp for the pump, and will let me know when she is back in the office next week. I will let you know! I'm half hoping it's not suitable for the pump. As convenient as it is, it's a hassle too!

rankearl
rankearl 2010-03-09 15:58:20 -0600 Report

i have hypo unawareness worse with the humalog since it reacts so fast wow insulin is exspensive at this time lily is is donating mine for now i myslef am not looking forwarded to taking shots again i say now i only take a sjot a week you know when i change my site let me know what elde you fnd out when i win the lottery or become president the world is going to change thanks agian for the info ((HUGS)) julie

Crashnot
Crashnot 2010-03-09 16:49:58 -0600 Report

You might see if Humilin R is still available. It's the first synthetic version and I was fine on it for 20 years. When I went over to the newer Humalog is when my problems started. If they still have it (can't recall if it's discontinued or not) you should be able to get it free too, as Lilly makes it.

dietcherry
dietcherry 2010-03-09 18:37:18 -0600 Report

Humulin R is still available; I'm on it and Humulin N. The newer insulins made me wreck my car-twice! Renee :)

Crashnot
Crashnot 2010-03-09 20:43:39 -0600 Report

Humalog is it's own type, there is no R or N for it. It is a fast acting version, like Humalin R is. The closest equivalent for Humalin N now is Lantus and Levemir.

Crashnot
Crashnot 2010-03-09 20:59:51 -0600 Report

For reference sake, the Humalin lines were introduced in 1983. Humalog came along in 1996, and in 2003 Lantus came out.

Eli Lilly discontinued offering the Humalin U Ultra Lente. L Lente, Regular Ilentin (Pork-based) and NPH Ilentin (Pork based) in 2005, which caused me some challenges as a long-time user. Novo Nordisk's Novolin L was also discontinued in 2003.

Another interesting note my searching found today was this quip:
In 1980, recombinant DNA ‘human’ insulin was first tested on 17 nondiabetic volunteers in England. The investigators concluded that ‘human’ insulin may be slightly more potent than porcine insulin at the low dose, and slightly less so at higher doses. They demanded ‘further and continuous careful observation of unexpected side effects’ [11]. The study predicted the problems with hypoglycemia unawareness seen later and which are discussed in the next chapter.

The book that came from was not identified because I'd love to read the "next chapter"!!!

rankearl
rankearl 2010-03-10 08:33:26 -0600 Report

thanks for all the info most pumps use humalog or novolog i think i did try reg humlin maybe i should try that again the last time i went to the clinic the usual dr i saw there said maybe you should move to canada we were just talking about there health care system but i have been researching about synthetic insulins diabetics in canada are lobbing their government for changes regarding synethic insulin due to so many deaths that says alot let me know if youn get anymore info thanks julie((HUGS))

jayabee52
jayabee52 2010-03-08 23:11:18 -0600 Report

Glad you took my suggestion in the other thread, Lisa. I may email my bride's endo and ask him about this report.

I've never taken anything other than Novo "N" insulin.

My bride takes Novo "N" Novo "R" and Novolog "Aspart"

It seems that (as I remember the report) the only reason these "human" insulins and now the insulin analogs were created was to create big profits for the pharmaceutical cos. That really chaps my hide!

It'll be interesting to see what the endo says about this.

Crashnot
Crashnot 2010-03-09 06:20:25 -0600 Report

I know my endo fought me tooth and nail when I announced I was going OFF the Lantus and then the Levemir she talked me into trying despite my protests. So I'm pretty sure I'll get a good deal of resistance to asking for a letter for the Pork (it will let me get govt. support as I am uninsured). Especially because she spent three years getting me to use a pump and I'm pretty sure I don't NEED a pump with the pork insulin.

When I was on it as a child using the pork/beef insulins, I took ONE dose a day for 16 years, and I was hunky, dory fine.

With the Humalin R and L I was taking 4+ shots a day, and of course with the pump it's hourly and my control is the worst it's ever been.

I don't really care for that math.

alanbossman
alanbossman 2010-03-08 20:00:33 -0600 Report

Thanks for the link and info Lisa. I do use lantus 18 units per day. So far i dont have any of those symptoms. I hope i never do. I do have memory lapses but i think thats just old age creeping in.
Alan

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