Just wanted to add this, and see if anyone of you have heard of this therapy…I have a lot of information on it, that I aquired, when my husband and I went to Dallas, TX., to meet with the people who own Diacare…The owner of the company gave this to me, when he found out that I had diabetes…If any of you have any input regarding this topic, please let me know!
The following is just a summary of the information, that I have regarding (PIVIT)
In the basal state and after oral ingestion of carbohydrate, the normal pancreas secretes insulin into the portal vein in the pulsatile manner. The end organ of the portal vein is the liver, where ~ 80% of pancreatic insulin is extracted during the first pass. In Type 1 diabetes, pancreatic insulin secretion is nearly or completely absent whilst in Type 2 diabetes the normal pattern is absent, abnormal, or blunted. Exogenous subcutaneous insulin treatment results in plasma insulin concentrations that are not pulsatile and a fraction of normal portal vein levels. Oral hypoglycemic agents also do not result in normal pulsatile response to a glucose load. Due to hypoglycemia risk, intensive treatment is not recommended after serious complications develop. Consequently, no conventional therapy has proved effective in treating advanced diabetes complications. Beta-cell replacement using whole pancreas or islet transplantation has been utilized to treat certain problems in Type 1 diabetic patients, but still unavailable for all diabetics. Pulsatile intravenous insulin therapy (PIVIT) is an insulin therapy, which mimics the periodicity and amplitude of normal pancreatic function. Numerous studies show PIVIT effective in preventing, reversing, and reducing the severity and progression of diabetes complications, however, the mechanisms involved with the improvement are not clearly understood.
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