Pulsatile intravenous insulin therapy: the best practice to reverse diabetes complications?

Sue Turner
By Sue Turner Latest Reply 2010-02-01 15:34:59 -0600
Started 2010-01-19 12:06:38 -0600

Just wanted to add this, and see if anyone of you have heard of this therapy…I have a lot of information on it, that I aquired, when my husband and I went to Dallas, TX., to meet with the people who own Diacare…The owner of the company gave this to me, when he found out that I had diabetes…If any of you have any input regarding this topic, please let me know!

The following is just a summary of the information, that I have regarding (PIVIT)

In the basal state and after oral ingestion of carbohydrate, the normal pancreas secretes insulin into the portal vein in the pulsatile manner. The end organ of the portal vein is the liver, where ~ 80% of pancreatic insulin is extracted during the first pass. In Type 1 diabetes, pancreatic insulin secretion is nearly or completely absent whilst in Type 2 diabetes the normal pattern is absent, abnormal, or blunted. Exogenous subcutaneous insulin treatment results in plasma insulin concentrations that are not pulsatile and a fraction of normal portal vein levels. Oral hypoglycemic agents also do not result in normal pulsatile response to a glucose load. Due to hypoglycemia risk, intensive treatment is not recommended after serious complications develop. Consequently, no conventional therapy has proved effective in treating advanced diabetes complications. Beta-cell replacement using whole pancreas or islet transplantation has been utilized to treat certain problems in Type 1 diabetic patients, but still unavailable for all diabetics. Pulsatile intravenous insulin therapy (PIVIT) is an insulin therapy, which mimics the periodicity and amplitude of normal pancreatic function. Numerous studies show PIVIT effective in preventing, reversing, and reducing the severity and progression of diabetes complications, however, the mechanisms involved with the improvement are not clearly understood.

10 replies

Sue Turner
Sue Turner 2010-02-01 15:34:59 -0600 Report

I think I am going to need an attorney to help me decipher this thing; it is very entailed and complicated information…LOL. I may be able to add more infomation or not! We'll see…:)

Libra1969 2010-01-21 17:20:48 -0600 Report

That is very interesting Sue and I for one would love to know more as you break it down. Thanks for sharing and if you please share some more.

Sue Turner
Sue Turner 2010-01-24 17:25:21 -0600 Report

Hi Libra,

I am working on it…It is very complicated, and parts of it is very hard to understand…So, I am working on it, picking it apart, and trying to put it in a way that we can all understand it…I have been battling with my BS for the past several days; it is either up in the 200s or bottoming out…Very frustrating…When it does this, it is hard for me to concentrate on anything, and make sense of it…I am type 1 and on the pump, you would think that I could get better control of it…

Harlen 2010-01-19 13:08:23 -0600 Report

Hi Sue
what info is that ???

Sue Turner
Sue Turner 2010-01-19 13:17:09 -0600 Report

Hi Harlen,

I am working on it, and trying to get all the info together…First and foremost, I wanted to know is anyone had heard of it…I will get it put together soon… Hugs, Sue

Sue Turner
Sue Turner 2010-01-20 11:49:25 -0600 Report


I have added just the summary of information regarding the (PIVIT) post…Maybe what I have added will explain a little bit about it…It is very entailed, and I have got a lot more studying to do about it…Maybe you will be able to get a little understanding out the information that I have added… Hugs, Sue

Libra1969 2010-01-19 12:32:03 -0600 Report

Hi Sue, what exactly is that??

Sue Turner
Sue Turner 2010-01-19 13:10:56 -0600 Report

Hi Libra,

I have a lot of info on it, that I will share with you later… It is very entailed, and I am trying to go through all my information and pick out excerpts that I can share with everyone that want take up too much time, and possibly explain it in a way that everyone can understand…As soon as I can get it all down, I will add it to my post…Bear with me, I am working on it…I wanted to go ahead and post this to see if anyone had heard of it…Thank you for you patience, Sue