By BIRDY Latest Reply 2009-11-11 00:14:15 -0600
Started 2009-11-10 03:13:25 -0600

Hi everybody ,

I created my account yesterday only and tried to check the previous discussions if I could find any word of HOMA-IR which indicates the insuline-resistance.
However I could not.My husband is prediabetic and the most important value the doctor concerns is his HOMA-IR. When he had his first test it was like 8.9 which shocked the doctor.Then he started taking Glukofage and his diet and 3 weeks later the new value was 1.89.
2 months later he had his last test and that time it was 3.8 which worse than the previous one .I don't understand why it was higher although he took the medicines, exercised and followed the diet regularly.Do you know something about this HOMA-IR ? I would be very happy if you share your experiments.
Many thanks.

15 replies

mmck 2009-11-10 23:11:07 -0600 Report

Hi Folks,
Recently joined the site, I was diagnosed as pre-diabetic a couple of months ago. After scared half to death "What on earth is this!?", I have settled down with the final test results: dramatically lower values when compared to the first tests. The reason was: lost weight with exercise, regular medications, diet, and the most important and effective of all : the support from my wife.

Here is some useful information that I have had collected from the net.
As stated above by friends HOMA-IR test is for indicating the Insulin Resistance:
Insulin resistance is an impaired metabolic response to our body's own insulin so that active muscle cells cannot take up glucose as easily as they should. In that situation, the blood insulin levels are chronically higher which inhibits our fat cells from giving up their energy stores to let us lose weight. This disorder is associated with obesity, hypertension, abnormal triglycerides, glucose intolerance (syndrome 'X") and Type 2 diabetes mellitus. The main problem is that this condition can exist unrecognized and metabolic damage can occur before a full blown Type 2 diabetes is finally diagnosed.
credits: Frederick R. Jelovsek MD

Hope this is helpful,
Have a nice day

BIRDY 2009-11-11 00:14:15 -0600 Report

Many thanks for everyone for joining this discussion and sharing knowledges and ideas.
I wish welness to everybody…

kdroberts 2009-11-10 10:55:26 -0600 Report

It's not a widely used test which is why there is probably nothing here regarding it. I would take a stab and say the diet is probably the issue if it it typical of what's normally recommended to diabetics the world over.

alanbossman 2009-11-10 10:36:56 -0600 Report

Hi Birdy, i found out that homa-ir is the measure of insulin resistance in your body. i take insulin shots and they say that if you are on insulin this test measure wont work for me. It works if you are on pills only


Andrew S. Rhinehart
Andrew S. Rhinehart 2009-11-10 10:23:31 -0600 Report

HOMA-IR is a measure of insulin resistance but is more of a research tool that is not used a lot in clinical practice. Insulin resistance is the cause of type 2 diabetes mellitus (T2DM) & pre-diabetes. Metformin does not specifically effect insulin resistance. Thiazolidinediones (TZD's) such as Actos (pioglitizone) and Avandia (rosiglitizone) specifically treat and improve insulin resistance. The problem is that insurance carriers will only pay for these expensive medications ($150.00/month) if someone actually has T2DM and not pre-diabetes; therefore, due to cost ($4.00/month) metformin is at times used to treat pre-diabetes. Metformin works mainly by decreasing hepatic glucose production (liver making glucose). Feel free to visit my website for more information regarding diabetes - www.TheDiabetesExpert.com

ptsparkle 2009-11-10 09:40:23 -0600 Report

Birdy, Welcome aboard. Sweetthing was correct, go on Google and type in HOMA-IR. You will find the questions you have answered. Good luck, and let us know how things turn out.

sweething 2009-11-10 08:41:29 -0600 Report

Boy, I'm stumped! I've had every test ever given to pre-and diabetics, and never heard of it. The test must be in your language; perhaps if you could ask his doctor what it is in English, or if it's the same?

My best wishes of good healthy and happiness.

BIRDY 2009-11-10 09:04:28 -0600 Report

Hi sweeting ,

HOMA-IR is an international term which is used for the insuline-resistance however I' m also surprised nobody heard it before.So , may I ask what term you use for the insuline-resisitance and what is your test result? Our latest result was 3.8 and I would like to know if this is an acceptable value for diabetics.

Many thanks…

alanbossman 2009-11-10 06:49:24 -0600 Report

Hello Birdy. i dont understand the term homa-ir I have diabetes and I am also insulin resistance but I take metformin 1000mg 2times a day and 18 units of insulin.You said your husband took glucophage, which is metformin. Is your husband type 1 or type 2. let us know what is going on


BIRDY 2009-11-10 07:29:13 -0600 Report

Hi Alan ,

Maybe HOMA-IR is a value which is used in Turkey.My husband is prediabetic.You're saying you have insuline-resistance too.What is your test result?His last test value was 3.8.
Thanks , thanks…

hbkunkel 2009-11-10 06:00:31 -0600 Report

I think you are actually referring to Hemoglobin A1C or A1C which is an average reading of your sugar level over the last three months. Good luck to both of you and keep us posted as to your progress and questions. We are a friendly group that is glad to help.

BIRDY 2009-11-10 06:23:13 -0600 Report

Hi Betsie ,

Many thanks for your nice wishes.
Actually HOMA-IR is a value which indicating the insuline-resistance. A1C test is another one he had and the value was between the normal values.In fact my husbands problem is not high blood sugar but high insuline-resistance which means the cells don't let the insuline go in.This causes weakness and more desire to eat.If the resisitance continous high , pankreas may give up producing insuline and that stage his problem will turn to diabet Type2.
Wish to welness everybody and greetings from a very warm and sunny Istanbul day.

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