My experience with the new classes of oral drugs treating insulin resistance has been weight gain and severe edema, especially in my lower legs and feet. So severe, I feared congestive heart failure, so I have elected to go off the new miracle oral drugs and stab myself with a needle again. The edema became so bad, that the top of my feet resembled pillows by the end of a day and only after 8-10 hours reclined, or flat in bed, did I find relief. The swelling also caused the skin on my lower legs and tops of my feet to change color, I assume from blood vessel damage. The doctor would never say what happened there, but not only did I have the swelling and skin changes, but severe pain in just massaging my legs etc. I am quickly finding relief as the drugs are leaving my blood system, and my legs have resumed their normal unbloated unswollen condition, and I am watching for the discoloration to go away too. Anyone else have experience with this? The oral agents I have tried, that caused all this swelling were Actos, Januvia, Avandia… those class of drugs that seem to work so well with resistance.
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