Why is there a problem with grapefruit but not other citrus fruits when it comes to medication?

By RebDee Latest Reply 2015-01-28 00:51:52 -0600
Started 2015-01-26 11:27:20 -0600

I know that I am not allowed to eat grapefruit but I don't know why. I especially don't understand why other citrus fruits are ok to eat while grapefruit is not. Any answers?

19 replies

valentine lady
valentine lady 2015-01-27 19:55:08 -0600 Report

Hi Dee
I have always been told the same about grapefruit. However. my pharmacist told me that does not hold true for
"Ruby grapefruit". I don't even know where to go to back that up but it would be worth the work to confirm or deny that. The red ruby is wonderful. Not as bitter and looks pretty too.
Good topic VL

jayabee52 2015-01-27 23:48:31 -0600 Report

Howdy Sweetness
I looked up "Ruby Grapefruit and P 450" in Google and got this as a result ~ http://www.pharmainfo.net/reviews/drug-intera...

It just mentions white and ruby grapefruit and then goes into the minutae of the chemical reactions in the body. This article does not differentiate the two grapefruit except by color. I would guess that that means that perhaps your pharmacist was mistaken about that. I would say, just to be on the safe side, take it for granted that they both have the same properties and effect on pharmacology.

Love ya


valentine lady
valentine lady 2015-01-28 00:51:52 -0600 Report

Hi Hon
Thanks for clearing that up. I really didn't know. I could only go by with what the Pharmacist said. I'll have to call him and let him know.
Love U

lilleyheidi 2015-01-27 00:50:26 -0600 Report

Reb, I've discovered a lot of times (most of the time) when I have questions like this, ask your pharmacist. They usually will know the answer, they know tons more about the medications the doctors prescribe than the doctors do.
I was on a med that said do not eat grapefruit, and asked my doc and the pharmacist explained the reasoning, but also said, one now and then on occasion would not harm me. As long as it was not all the time. I love grapefruit. So, I'd ask your pharmacist if it's okay to have one on occasion. Best of luck to you, Heidi

StephD143 2015-01-27 08:26:55 -0600 Report

Heidi…I could NOT AGREE MORE. I visit my local pharmacist all the time for answers to my medications. The thing with primary doctorsis that they have the advantage of knowing our medical history which is a big plus. But I have built quite the relationship with my pharmacist and he knows me pretty well. I also take him all the OTC stuff I'm taking so he can take a look at it. I think that's also why I felt so good about taking the supplement I'm on because it was made by a pharmacist, and with my experience they know more about medications than anyone else!

Jibber Jabber
Jibber Jabber 2015-01-26 15:25:18 -0600 Report

My mother's doctor told her when he put her on Lipitor a million years ago..(she has since stopped taking it)…that grapefruit for some reason interferes with the livers ability to process certain medications…I don't know how true this is…as many doctors just parrot things that they have been taught in med school…and we all know what they are taught is sometimes wrong…BUT he also told my mom at the time that whenever she is given a new med to take…that she should refrain from eating grapefruit until she finds out if it is okay..because some doctors do not warn their patients about the liver processing issues and just cut scripts..

jayabee52 2015-01-26 13:54:33 -0600 Report

Howdy Dee
I queried Google re this question and found this: "Cytochrome P450
comprise a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm."
More, see ~ http://www.medchemexpress.com/Targets/Cytochr... (I know, Dee I don't understand it completely myself.)

There is another orange which has the same properties, the Seville or "bitter" orange see ~ http://www.consumer-health.com/services/cons_... Otherwise the sweet oranges do not have the same properties

That is the best I can do to explain the why question


GabbyPA 2015-01-27 13:52:21 -0600 Report

I think in short it might just be what makes the fruit bitter that is the problem. Though lemons and limes are sour or bitter too...hmmmmm. Makes you wonder.

Just Joyce
Just Joyce 2015-01-26 12:33:05 -0600 Report

Research the medications you are taking. You can not eat grapefruit with some medication. Some are medications for high blood pressure.

StephD143 2015-01-26 11:32:31 -0600 Report

did the doctor specifically say it was because of the medication you were taking? I have low blood pressure normally and my primary has told me in the past not to over do the grapefruit because it is a natural diuretic and can put my BP on the floor.