I read that Diabetics who take metformin may experience slow drop in their B12 levels that can produce symptoms similar to periphial neuropothy. The article, published on WEBMD, gives the full details. I have several kind of anemia (but not pernicious anemia that requires frequent injections of B12) and migraine headches (for which I take another prescribed medication), and also take a PPI for GERD. After researching B12 and the body's metabolism of the assorted meds I take, I began taking 500 mg of B12 twice a day even though I knew that we get an adequate supply eating meats, and that B12 is best absorbed through injection and not in our gastro system. I was surprised that I felt less encumbered by the constant low grade head ache. I'll answer any questions as to where I found my answers on the Linus Pauling nutritional web site at oregon State University web site.
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