By thebabylez Latest Reply 2014-10-19 18:21:45 -0500
Started 2014-10-15 09:45:40 -0500

I was diagnosed as kid with type 1. No one in my family history has ever had type 1. Anyone have any thoughts about how I have a "genetic" disease?

6 replies

HawkinsD 2014-10-19 16:16:13 -0500 Report

I don't know if they have found the genetic component for those of us who are first generation diabetics, but I do know that our biological children are likely to develop this disorder. I have two adult children who are both Type 1 diabetics. The study goes on…

L.Chancellor 2014-10-17 13:50:42 -0500 Report

I am in the same boat as you. I am the only type 1 in my family. From my understanding and what I was told is that Type 1 diabetes is an autoimmune disease. Meaning that the body attacked itself causing the pancreas pretty much to "shut-down" which can lead to diabetes. In my case I had caught a bad cause of strep throat and upon the diagnosis found out that I was diabetic. Not all people respond the same, if that were the case then everyone would become diabetic after a cold! I might be wrong in exactly how I worded everything but here are some useful links that helped me when I first found out. The information is out there. Just make sure that you go and read it for yourself.



This last part is from wikipedia.

The cause of type 1 diabetes is unknown.[4] A number of explanatory theories have been put forward, and the cause may be one or more of the following: genetic susceptibility, a diabetogenic trigger, and/or exposure to an antigen.[16]

Main article: Genetic causes of diabetes mellitus type 1
Type 1 diabetes is a disease that involves many genes. Depending on locus or combination of loci, they can be dominant, recessive, or somewhere in between. The strongest gene, IDDM1, is located in the MHC Class II region on chromosome 6, at staining region 6p21. Certain variants of this gene increase the risk for decreased histocompatibility characteristic of type 1. Such variants include DRB1 0401, DRB1 0402, DRB1 0405, DQA 0301, DQB1 0302 and DQB1 0201, which are common in North Americans of European ancestry and in Europeans.[17] Some variants also appear to be protective.[17]

The risk of a child developing type 1 diabetes is about 10% if the father has it, about 10% if a sibling has it, about 4% if the mother has type 1 diabetes and was aged 25 or younger when the child was born, and about 1% if the mother was over 25 years old when the child was born.[18]

awall4 2014-10-15 17:15:26 -0500 Report

I am in the same boat. No one in my entire family on either side has ever been diagnosed with type 1 or 2. I have a theory though about how it happened. As a kid I started immunotherapy for environmental allergies, a main component of those drugs were steroids. So I suspect it was caused by steroids or steroid induced diabetes. Although it is commonly connected to type 2. Not necessarily genetic but anything is possible considering no one can tell me why it happened.

jayabee52 2014-10-15 12:10:50 -0500 Report

Howdy Lez.

There may be more evidence that us T2s have the genetic disease (actually more like a predisposition to diabetes) than T1s.

Really what does it matter what mechanism gave us the Dx of any form of Diabetes? The main thing now is to use the best standard of care we can to keep this disease at bay.

God's best to you


Nick1962 2014-10-15 12:10:47 -0500 Report

From my reading, Type 1 isn’t solely a “genetic” thing. There are many genes involved with diabetes and even in twins, one sibling can have it and only about 30-50% of the time the other will. With the amount of genes that make a human, we are supposedly like snowflakes – no two will ever be exactly alike (although I know a mathematician who will emphatically deny that theory).

Viruses, chemicals, drugs – really your environment when you were born may have also played a part. The stem cells that would have been assigned to become the insulin-producing beta cells in your pancreas may have been needed elsewhere to repair a deformity or boost resistance to some substance or another. We are all imperfect – some in many ways – and chances are your parent’s genes together produced that one perfect cocktail that became you, but unfortunately as a T1.
Just my thoughts anyway.

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