"Brazilian Lite" Cocktail...Cure for Type 1?

By GabbyPA Latest Reply 2014-07-10 06:38:35 -0500
Started 2014-07-03 07:12:33 -0500

I was reading about this years ADA conference on DiaTribe and found an interesting article that involved two drugs mixed (thus the cocktail) that helped people with type 1 produce insulin. It is in the beginning stages and came with some big issues that have to be worked on, but it was encouraging news.

Here is part of the conference article. http://diatribe.org/issues/65/conference-pear...

It was refreshing to see positive results again, after a bit of a drought, from research focusing on a type 1 cure. Dr. Michael Haller presented the results of a trial measuring the effects of a low-dose combination of antithymocyte globulin (ATG) and granulocyte colony stimulating factor (GCSF) in patients recently diagnosed with type 1 diabetes. This drug combination, called the “Brazil Lite” cocktail, is a radical treatment for type 1 diabetes that essentially resets the immune system by replacing the body’s T-cells to prevent attack on the beta cells. The results of the study showed that people taking the Brazil Lite cocktail retained their ability to secrete insulin (“C-peptide”), whereas those on a placebo saw a decline, and insulin independence was achieved in all 65 participants at least once during the trial. Unfortunately, the Brazil Lite cocktail did not result in a reduction in A1c. This treatment is notable as one of the first that addresses the fundamental cause of type 1 diabetes (autoimmune attack), instead of the symptoms. However, the positive results came with a major safety risk: 34 of the 65 patients in the treatment group experienced cytokine release syndrome and/or serum sickness, which result in unpleasant fevers and allergic reactions. While these safety risks outweigh the benefits of such an extreme treatment, the trial provides a glimpse of new type 1 therapies. Scientists are also working to make a safer version of the Brazil Cocktail as well as other new therapies in early-stage trials.

To read more about type 1 cures and treatments on the horizon, please read our book on the topic called “Targeting a Cure for Type 1 Diabetes” at diatribe.org/cure.

12 replies

grandma sila
grandma sila 2014-07-09 21:35:15 -0500 Report

thanks for the info. I heard cinnamon was good for high cholesterol but didn't know it was good for lowering blood in type 2 diabetes. I am going to try to use more often . Thanks Gabby for your reserach.

GabbyPA 2014-07-10 06:38:35 -0500 Report

Actually cinnamon is good for maintaining good sugar levels. It doesn't reduce it. I still encourage consuming it and you want to consume the right type. Cyleon is the one you want, and that is generally not the one you get from the grocery store.

Trudie Ann
Trudie Ann 2014-07-05 14:05:04 -0500 Report

I hope they do find a cure for not only diabetes, but cancer and everything. I do think they will but not in my life time. Of course I never dreamed some of the things going on would ever happen in my life time either. Thank you Gabby for all the info you post. I never seem to have enough time on the computer to do research and every thing I would like to.

grandma sila
grandma sila 2014-07-03 21:24:35 -0500 Report

thank you I have type 2 and using medformine . I probably spelled that wrong. Just now learning about everything.

Just Joyce
Just Joyce 2014-07-03 10:38:58 -0500 Report

Interesting. I was reading about being able to snort insulin. I hope it works for T1's because a cure for T2 might not be far behind.

jigsaw 2014-07-03 09:51:36 -0500 Report

It's encouraging, along with snorting insulin! Yes, there are encouraging things happening on the horizon!

GabbyPA 2014-07-03 09:33:09 -0500 Report

I know it's still kind of a pipe dream as side effects of over 50% of those who participated were severe, but it's a start

jayabee52 2014-07-03 09:12:54 -0500 Report

As a T2 I pray that something really useful comes out of this line of investigation, like a REAL cure for T1!