Byetta Injection Meds

Mikeymike - 15933
By Mikeymike - 15933 Latest Reply 2009-02-04 17:54:06 -0600
Started 2008-06-03 12:53:32 -0500

I just started this new medication called Byetta it is an injection type has any one ever heard of it I take 5 mcgs twice a day with meals. Its been five days and I realy haven't seen any differance. If any one has tryed this can you help me out?????????

28 replies

Bluebutterfly 2009-01-13 05:59:40 -0600 Report

i took byetta for six months and I couldn't tell any difference in weight loss or bs.I take avandia,metformin.junuvia and glyburide. With so much medication my sugar runs low in the morning.This is the last thing to try before I am put on insulin. 2009-02-04 17:54:06 -0600 Report

I've been on Byetta for 1.5 yrs, I lost 55 pounds with it. it lowered my Blood sugar in the am it has been running about 87. It can help you. But and there's always a but. I am going in for new knees and my dr did a pre op. My Lipase was 1199 and the norm is 0 - 60. I went to a specialist, the Byetta caused Acute Pancreatitis. One of Byetta's side effects is that it can do this. Acute pancreatitis induced by drugs (as it was called) Go to your DR have this level checked, they don't do it in a normal blood test, you have to ask to check your "Bilirubins", which is part of a Liver test. If you read the Byetta website it can cause this in people. My Dr never told me this when I started this, she never checked this. I switched doctors a month ago and my new doctor ran this & I found this out. Byetta can cause Acute Pancreatitis, go to your doctor and be checked.

Tessie - 20674
Tessie - 20674 2008-08-19 10:58:39 -0500 Report

I took byetta for about 6 months, I lost weight on it, my appetite was not as great, it helped my blood sugars to a degree but about the 6th month I felt my body was becoming toxic from it. It could have been a start of pancreatitis. You have to be careful. Check out an article on about death's linked to Byetta.

Goddess 2008-08-16 12:24:39 -0500 Report

I was on glipizide and byetta. I noticed with the glipizide my BS increased to almost 400. Doc took me off of the glipizide and my BS are in the 100's with Byetta alone.

Evilannie 2008-08-03 07:26:24 -0500 Report

Byetta is not used in conjuction with insulin. It is used before insuln.

shepherdsrgrt 2009-01-11 08:07:19 -0600 Report

I am on Byetta (5) and not seeing much change in sugars. Some are under 200 and directly after meals they are good. But it seems to work like a fast acting insulin and only gives me results an hour or so after my meals. I am also on Humalog (short acting insulin) and Levemir (long acting). They both seem a waste since my numbers are not great. I'll be asking the dr. about increasing byetta to 10 and hope to see some major changes. I have lost 10 lbs. and my A1C dropped 1 pt in 3 months-not a great accomplishment to me since I'm poking myself atleast 7 times a day between the Byetta, humalog and levemir. Any thoughts? My dietician says I'm extremely carb sensitive so I need to basically cut out any/all carbs I can. Yummy!!! Feeling a bit deprived but…

John Crowley
John Crowley 2009-01-12 11:47:14 -0600 Report

I guess success is all a matter of perspective. Dropping your A1c a full point in 3 months seems like a great step in the right direction to me. As is 10 lbs of weight loss. I'm sure you were hoping for more, but still you've made important positive progress in 3 months. Keep it up and see where the next three months can take you.

Anonymous 2008-07-12 05:47:22 -0500 Report

I was on byetta injections for 8 months. couldn't take the evening injection because it dropped my bg to less than 60. went to one shot a day and it was not enough. I did loose 20 lbs but couldn't control my bg. I now have been put on Lantus insulin just started it so we'll see. Anyone familiar with lantus solostar?

DJ 2008-08-27 00:26:25 -0500 Report

Hi, I use the Lantus Solostar pen, and I love it…I am up to 20units every night before bed, and my morning BG has been super, as long as I watch what I am eating for dinner, and have a small carb snack before bed(with-out the snack,you run the risk of going to low..or at least I do)my waking Bg's have been around 76-95 and for me that is wonderful.Let us know how it is working for you..K

Donna Mellow
Donna Mellow 2008-06-21 09:48:03 -0500 Report

I also take Byetta. I take 10 mcg. 2 times a day with Metformin. I don't like to inject myself, but I have to say, This medication is the only one that keeps my glucose level normal. This medication also helps you lose weight. Do you take anything else with the Byetta?

bgtcars 2008-06-17 05:01:24 -0500 Report

I have used Byetta and it did wonders for me . I have been on the 10 and 5 dosage , and the biggest thing it did was I lost about 80 lbs. and my glucose levels are about 65 in the morning and stay good all day as long as I do my part. The Dr has taken me off of the shots for now and am only taking gluberide in the morning. For the 5 years before my sugars ran as high as 500 to700 and went through 2 Doctors to get it right. Stay with it and it will seam like all of a sudden it justs clicks in to work. Now I can get aropund some and feel much better.

LdyRs 2008-06-16 18:04:17 -0500 Report

I've been on byetta for awhile and when I use it, religiously, I lose the weight, have more energy and feel tons better. Food is just another thing to do for the day, not a necessity. I'm conquering arthritis and gout in my knees and have used the byetta. I'VE LOST 40LBS IN 8 WEEKS! It does work, however, Mikeymike, I'm on two injections of 10mg a day. My best thing about it besides the weight loss is the injection is totally, painless! Give it another chance. (smiles)

MaryC - 17518
MaryC - 17518 2008-06-16 06:00:17 -0500 Report

I take Byetta too. You really don't see a difference but I noticed my clothes are loose. You can go up to 10 if you don't see results talk to your doctor about it. I was on 10 but it was too much for me and I would get sick right after I injected myself.

Lisa 1965
Lisa 1965 2008-06-16 04:10:05 -0500 Report

I have been on byetta 10mg twice a day for over a year now. It took about a month or so for my sugars to look better, however I love it! My sugars have been better, my A1C is alot better! My employer dropped our health insurance so now I dont know how I will be able to afford to keep taking it as it is pretty pricey for a 30 day supply, but I will try and find a way. I am on that and on 4mb avandia a day. That is it. When I was first diagnosed 6 yrs ago with diabetes, I was on insulin, and three other pills, now i am on byetta and 1 pill and feel great. I did lose some weight but no big thing, I feel good! Best of luck to ya!

spoiledrotton 2008-06-15 03:36:34 -0500 Report

I take the byetta shot but i can't see a lot of differance. I dont seem to eat as much but I'm not losing any weight.

kdroberts 2008-06-14 06:26:45 -0500 Report

This is going to sound rude towards some of the replies but it really isn't my intention to be. I'm just concerned about the mis-information that is being given to patients or from what people read online and then passed on from here.

Firstly, Byetta does NOT help injected insulin such as Lantus or Novolog work better. Secondly, the primary function of Byetta is to lower blood glucose.

It is one of the newer drugs and has 3 main, documented functions, weight loss is not one of them. Some people do loose weight whilst on it but it is not (as of now) one of the documented functions of it, it appears to be more of a side effect. It is a synthetic hormone of a hormone that a lot of type 2 diabetics have low amounts of, GLP-1. The function of the hormone is to signal your pancreas to increase the production of insulin when your blood sugar is rising after you eat and then cut it back when your blood sugar is back to normal. If you don't have any, or low levels of the hormone your blood sugar will rise, your pancreas will not produce enough insulin and your blood sugar will end up going too high.

So, the number 1 method of action. You take your Byetta before you eat. When you eat and your blood sugar rises, the Byetta signals your pancreas to produce insulin, your blood sugar rises, your insulin level rises, the insulin works out the sugar and your blood sugar levels stop rising and then start coming down. If the lower dose doesn't work enough, then you may need the larger dose to signal your pancreas.

The second method of action of the hormone and Byetta is that it slows down the speed that food passes through your digestive system. With low levels of GLP-1 food gets digested and absorbed into your blood stream quicker than it should. The faster that happens, the faster carbs will increase your blood sugar. Slowing it down has 2 effects. The first is that it will slow down how fast the carbs hit your blood stream so you will get a slower and lower rise in blood sugar. The second is that you feel fuller when you eat because the food isn't passing through you so quickly. I think this is where the weight loss comes in too, you eat less so a lot of people lose weight.

The third method of action is very similar to metformin. It reduces the amount of sugar that your liver stores, produces and releases into your blood. I believe the way it does this is partly to inhibit glucagon which is the hormone that your pancreas uses to signal the liver to release glucose.

Because of the way it works, it is no good for type 1s as it mainly relies on the bodies own ability to produce insulin, something type 1's can't do. It can be used on it's own or in combination with insulin, metformin, TZD's (actos and avandia) or sulfonylureas (glyburide, glipizide, etc). My personal feeling is that metformin, TZDs and insulin should be considered before sulfonylureas because sulfonylureas stimulate the pancreas to produce insulin as does byetta.

As with all diabetic drugs, it can only do so much. Your diet (most importantly carbohydrate consumption) and your level of physical activity will play a much bigger overall role in managing diabetes and how well any medications you take work.

I'm not a doctor so take this how you wish. I get my info from doing a lot of research into the various diabetic drugs, how they work and how the positives and negatives of them. This includes talking to doctors, pharmacists and people who take them.

bucky 2008-06-15 00:38:57 -0500 Report

@ Kdroberts Incretin mimetics for type 2 diabetesFrom HealthwiseExamplesBrand Name: ByettaChemical Name: exenatideExenatide is the first of a new type of medicines called incretin mimetics. The U.S. Food and Drug Administration (FDA) approved exenatide to treat people with type 2 diabetes who have not been able to control their blood sugar levels with oral medicines. It is given as a shot 2 times a day, before morning and evening meals. How It Works: Incretin mimetics act like (mimic) the natural hormones in your body that lower blood sugar. These hormones are called incretins. Exenatide:·a)Allows your pancreas to release insulin. This drug lowers blood sugar levels only when they rise too high. · b)Prevents the pancreas from giving out glucagon. Glucagon is a hormone that causes the liver to release its stored sugar into the bloodstream.

second thing that i found

Weekly med helps Type 2 diabetics
A new, once-weekly version of the diabetes drug Byetta controlled blood sugar better than the standard twice-daily dose in a recent study, researchers have found. Patients in the 30-week study were divided into two groups, some of whom took the standard, twice-daily dose, while others took the long-acting version. Researchers say that over three-quarters of the patients who took the long-acting version of Byetta achieved optimal blood sugar levels, compared to 61 percent of the patients who took the twice-daily dose.

So with what i have found i beleive is that this drug DOES help lower your blood suger (witch is one of the reasons why my not 1 but 2 doctors advised me to take it with my other 2 injections.

kdroberts 2008-06-15 02:41:29 -0500 Report

I never said it didn't help lower blood sugars, I said that was it's primary function. The GLP-1 hormone I talked about is how it does it.

I did say that it doesn't help your injected insulin work better, because it doesn't.

I am aware of the trials into the once weekly version of it, they have been working on it for a while.

Dancehawk 2008-06-15 05:26:52 -0500 Report

It does help you loose weight too, A lot of doctors are putting folks that are pre diabetic on it to help them loose weight before they agree to ok the lap band.
And with a healthy diet you do notice your sugar going down.
Just like any drug, it will vary from person to person, and what works for one may not for another.
I am learning it is a hit and miss.
Like Metaphorm I had a sever reaction to Byettas working for me.


Sloan 2008-08-03 05:55:00 -0500 Report

Byetta is the injection and Januvia is the same thing in pill form. The average wt. loss is only 5 lbs. SO if anyone has lost more than this, YOU have done a great job. Our office uses a lot of Byetta mainly for type 2 diabetics. I am a pumper, but have tried it. I lost about 5 lbs. and it made me so sick, it just wasn't worth it. Sloan

kdroberts 2008-08-03 08:37:45 -0500 Report

Byetta and Januvia are not the same things. The end result is similar ways but Januvia inhibits the DPP-4 enzyme and Byetta is a synthetic form of the GLP-1 hormone. DPP-4 inactivates the GLP-1 hormone so inhibiting that means you need less GLP-1 to do the same job, Byetta just means you have more GLP-1. As far as I know, there are at least 3 other DPP-4 inhibitors that have been submitted for FDA approval.

Dancehawk 2008-06-04 17:00:40 -0500 Report

Are you eating healthy?
what are your suger readings each morning and bed time reading?
Also whats your normal meal like, we can try to trouble shoot whats going on.
you should notice a drop each week, not only in blood but weight too.


deetz 2008-06-14 05:10:30 -0500 Report

I've been taking Byetta for several days and was curious as to who told you it would make your blood sugar level go down a point? I was never told this. I read everything I could about Byetta, prior to using it, and weight loss was mentioned, but nothing about sugar levels going down. Mine still changes from day to day…not continuously down.

bucky 2008-06-04 16:39:26 -0500 Report

Are you takin insilin as well?? like lantin or novilog?? i ask cause i take it to help my insilin work better. plus for some it also helps to lose weight.

Dancehawk 2008-06-16 09:38:22 -0500 Report

Byetta you ll loose about 5 pounds or so by its self over 3 months but combo it with healthy meals and exercise