MODY...Do You Have It?

By rbergman Latest Reply 2009-01-31 11:49:34 -0600
Started 2009-01-29 11:55:05 -0600

I just found out my daughter will be tested for MODY, (Maturity Onset Diabetes of the Youth). I found a few websites on it and some helpful information I'm wondering if anyone here has it or knows someone that does by chance for a little more insight on the subject.

3 replies

kdroberts 2009-01-29 12:06:18 -0600 Report

It's thought to be rare. It's basically some form of genetic problem that leads to insulin production problems and there are a number of different types. I believe one type is so rare that it appears to be specific to a single family but the rest are possible for anyone to get. Different ones are more prevalent in different countries, for instance MODY 3 is the most common type in Europe. It's still pretty early in terms of understanding so information is sparse.

The two best treatments are either insulin or a sulfonylurea I believe.

rbergman 2009-01-29 12:30:13 -0600 Report

This is what I did find online:
The following characteristics should warrant consideration of a diagnosis of MODY in hyperglycemic and diabetic patients:

* Mild to moderate hyperglycemia (typically 130-250 mg/dl, or 7-14 mM) discovered before 30 years of age.
* A first degree relative with a similar degree of diabetes.
* Absence of positive antibodies or other autoimmunity (e.g., thyroiditis) in patient and family.
* Persistence of a low insulin requirement (e.g., less than 0.5 u/kg/day) past the usual "honeymoon" period.
* Absence of obesity (though obese people can get MODY), or other problems associated with type 2 diabetes or metabolic syndrome (e.g. hypertension, hyperlipidemia, polycystic ovary syndrome).
* Cystic kidney disease in patient or close relatives.

The diagnosis of MODY is confirmed by specific gene testing, now available through several commercial laboratories.

Their thought on this is because of the gene factor, she being a 6th generation diabetic, the fact that she is so young and she also has auto-immune failure which caused the thyroiditis. Just enough strikes against her that her new Doctor wants to run the tests more to rule it out than it is to confirm she has one of these types of Diabetes. But I would still like some first hand information from anyone who is dealing with this type of Diabetes if at all possible.

rbergman 2009-01-31 11:49:34 -0600 Report

It seems these forms of Diabetes aren't well known, on Feb 6 my daughter is being tested, I'll pass along any information that I find out for those interested.