Metformin vs Glyburide

Montreal Rick
By Montreal Rick Latest Reply 2013-08-21 22:08:37 -0500
Started 2013-08-02 13:15:27 -0500

I was diagnosed with Type 2 Diabetes 4 years ago. At the time I weighed 280lbs (I'm 5'10" tall). I was put on Metformin and insulin (12 unit once a day).
Since that time, through changes in my diet and plenty of exercise, I have managed to get my weight down to 190lbs, where it has been fom almost 18 months now. After my last physical exam and A1c test, my doctor decided to take me off of Metformin and put me on Glyburide instead, he joked that I almost no longer could be considered Diabetic at all!
I've done some research on the differences/benefits between Metformin and Glyburide and wanted to inquire of the Community if anyone could advise me regarding any experiences they may have had regarding any weight changes that maybe I can expect, i.e. will I have to change my diet again? I am currently eating a high protein/low carb diet, with plenty of fruit (especially grapes and bananas) and nuts. I also walk and ride my bicycle for any trips less than 5 miles and walk my dog a mile to and from the park, twice a day for exercise.

6 replies

Nora3452 2013-08-21 22:08:37 -0500 Report

Hi Rick, Glyburide is a sulfonourea (it forces your pancreas to produce more insulin), and Metformin helps your insulin work better by making the insulin receptors in the body more sensitive. There are not too many long effects from the two medications.

You do raise an interesting question about low/carb diet and interaction with the two drugs. You should pose the question on Healthtap, where you can ask a free questions to a large online community of doctors. They usually get back to you in a few hours. I found a question here that's similar to yours asked by someone else:
Hope it helps!

MOGOJO 2013-08-13 08:22:54 -0500 Report

I am a type 2 also, I take Glyburide and I have no problems. When I took metformin, my heart starting to race and stuff. If I eat fruit, my sugar does go up. This has always been a problem for me. Good luck.

Montreal Rick
Montreal Rick 2013-08-13 19:34:15 -0500 Report

I have had the same sort of results…with Good Diet, Exercise, and some weight loss, things seem to have settled down, metabolically speaking…
BTW - one of my favorite snacks is/are dried Dates - (been eating them since I was a Kid - so for over 40 years), turns out that this was a bad thing- as far as a Diabetic is concerned…so I'm saying, "Beware of dried fruit, check the numbers, and ingest accordingly."

correctionsnurse1 2013-08-09 12:14:40 -0500 Report

First of all huge congrats on the huge weight loss! Great job! I actually prefer the Metformin over Glyburide as Metformin if you will, helps to "stabilize" blood sugar levels. But with that said, your Dr. is the one that has the "MD" behind their name :-)

Montreal Rick
Montreal Rick 2013-08-10 08:58:56 -0500 Report

BUT doctors (IMHO) although they present everything they say as fact, are in actuality, merely giving their Informed Opinion. It's true that, having lost a lot of weight, my BG numbers have improved and stabilized, but I'm uncertain whether it's because of the medications, or if it's due to adding Glucocil to my regimen in addition to a low carb, high protein diet…

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