UAB researchers manage to cure type 1 diabetes in dogs through a gene therapy

By jayabee52 Latest Reply 2013-03-07 02:52:50 -0600
Started 2013-03-06 10:41:46 -0600

This morning a new friend, Josep Maria sent me a link to an article in Catalonian (Spanish) about a promising treatment for dogs with T 1. The original link Josep supplied may be found here ~

After picking through the untranslated article with my meager language skills I decided to see what a translate program (I tried Bing this time) would do. The following is a translation of this article as translated by Bing

UAB researchers manage to cure type 1 diabetes in dogs through a gene therapy

ACN Barcelona | Updated on 07/02/2013 15: 56

It is the first time that demonstrated the effectiveness of a treatment in large animals

Researchers from the Universitat Autònoma de Barcelona (UAB) have managed to completely cure type 1 diabetes in dogs by a single gene therapy session. It is the first time I got cure this disease in large animals and this sets the basis for a future can be transferred to human therapy. This therapy consists of a single session multiple injections of gene therapy vectors to the paws of the dog. The goal is to express the people of insulin and the glucoquinasa to make the function of "glucose sensor" to get an automatic regulation of blood glucose uptake and reduce diabetic hyperglycemia.

The study is published in the journal ' Diabetes ' and was directed by Professor Fatima Bosch. Tracking the animals has been made for over four years in some copies and in any case have re-emerged symptoms of the disease.

The therapy is very little invasive and involves multiple injections at one sitting with simple PIN (like the ones used in cosmetic treatment) through which are inserted gene therapy vectors to express the gene of insulin and glucoquinasa, the latter to act as a regulator of blood glucose uptake. When the two genes act simultaneously do the function of "glucose sensor" and got an automatic regulation of uptake of glucose from the blood and reduces excess glucose associated to the disease known as diabetic hyperglycemia.

This treatment has been proven safe and effective. The vectors involved are called "adenoassociated" and derived from non-pathogenic viruses. Animals to which they have applied the therapy showed a good glycemic control at all times, both fasting and after having eaten, and better than dogs who received daily injections of insulin. In addition, there were episodes of Hyperglycemia or after exercising. Dogs participating in the study were also normalize your weight and did not develop secondary complications after four years of treatment.

This type of therapy had already been used on mice, but now the UAB has made it for the first time in large animals. This is an important step because it lays the groundwork for a future veterinarian will take a clinical trial for the treatment of disease in companion animals and, later, in humans.

The research was led by the Director of the center of Animal Biotechnology and gene therapy at the UAB, Fátima and with the participation of Bosch, various departments of the UAB and the Children's Hospital of Philadelphia and the Howard Hugues Medical Institute of Philadelphia. [end translation]

So a cure SEEMS to be getting closer for those afflicted by T 1.

How it will turn out for humans is anyone's guess.

Thank you Josep Maria for sharing this news with us! It seems very hopeful! As a T 2 I will rejoice with T 1s when finally a workable solution (cure?) is found for T 1 Diabetes Mellitus

James Baker

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