By dietcherry Latest Reply 2014-01-07 05:02:47 -0600
Started 2012-02-07 16:28:59 -0600

I saw my Endo a couple of Fridays ago and we discussed my A1c's, which are always below 6.0 and this most recent one was 5.0. However, keeping these low numbers has contributed to many many hypoglycemic reactions, some involving seizures. I told him that I cant live this way anymore and asked for help.

He brought up an interesting premise: the possibility that I am insulin resistant. At first glance, I know this appears counter-intuitive because of my low A1c, but he has always felt my daily insulin dose was twice as much as it should be. I have consistently tried to lower it in the past but would encounter too many highs.

His suggestion was for me to use Metformin on a trial basis to determine if in fact I am insulin resistant. Apparently this is a possibility for T1s after many years, in my case 32.

Ive been on Metformin ER 500 mg. daily for a week now and we cut my insulin back to half my former dose.

Some positives:

I still have lows because of my Hypoglycemic Unawareness but they dont leave me on the floor unable to walk, talk, and often seizuring.

I feel really good on this med and dont experience blood sugar boomeranging like before.

Some negatives:

This drug is suppressing my appetite to an incredible degree! This would be a great side-effect for some, however I dont need to lose weight.

The gastro-intestinal distress comes and gos. Somedays Im fine, the next, Oh Dear God! I cant keep enough toilet paper in the house!

I dont know at this point if I am resistent and this is helping with that OR if Im just not hungry so am not eating like I use to, which believe me, I can put away some food!

I realize its mostly T2s that use this med and I would be forever grateful if any of you would care to share your experiences with its use. ANYTHING you think is important, I would love to hear!!!!!

137 replies

karen7t2 2014-01-07 05:02:47 -0600 Report

I am on Metformin and have been since being diagnosed last May with T2. I find it has really decreased my appetite and I wasn't eating enough calaries in a day to sustain my weight. I lost at least ten pounds very quickly, but seem to be able to eat more now. I am just struggling on what to eat. Anyway, the weight loss slowed considerably after about 4 months. Hope this helps.

rk_minor@yahoo.com 2012-02-20 17:58:43 -0600 Report

I have been on Met for almost 2 years now and just started having a loss of appetite. Dr. said he could not think it was the Met causing this but was unsure. I am on no other meds that would cause this problem.

dietcherry 2012-02-20 21:48:54 -0600 Report

Well now thats interesting! As you can see, I lost my appetitie initially but it has returned; however, my stomach must have shrunk in the interim because I cant eat the same amount of food I did before Met without getting a stomachache.

I dont know anything else about Met; maybe another member will see your inquiry and answer. Or we have access to Drs from Joslin who can help. Find them on the Home page, right-hand side, under Joslin Diabetes Experts :)

MoeGig 2012-02-15 19:39:01 -0600 Report

Hey DC..Just got back from the endo. Worried about waking up to a bedroom full of emt's that happened again a couple of weeks ago. He suggested not taking novalog before bed regardless of blood test. I take small amount of Lantus in the PM and let that slowly bring down a high evening blood sugar…200-300. Set your alarm for 2am and check bg. If it's 100 or less, take something at that time (ginger ale for me). And, third, a teaspoon of peanut butter (protein) before bed (regardless of test) because the protein will help slow down the drop. He also said, aim for an A1c less than 8 instead of 7 (my goal). My last one was 6.8 which is still fine. (I know you aim for the 5's…he would say that's way too low to target).

All I know is, I have to avoid these hypoglycemic attacks at all cost. They're potentially quite deadly as we know.

Hope all is well.

dietcherry 2012-02-15 20:04:19 -0600 Report

Hey Moe! Please take good care of yourself! I dont want anything to happen to you!!!
Since starting Met, my Endo cut me waaaaaay back on insulin cuz we are testing the theory of resistance. My sugars are running higher now; the Met doesnt seem to be doing anything for me since my appetite returned. ??? Im taking my numbers to him this week for a consult so we will see :)

Moe I heard so many horror stories growing up of someones diabetic grandmother going blind or being an amputee and it scared me from ever letting my BG run high, even for a while, you know? Control can be an elusive balance for we T1s…

snuggles071 2012-02-14 15:04:34 -0600 Report

i was diagnosed type 2 in june 2011,im on metformin 500 mg a day my a1c was 10.8 now it has stayed at 5.8 since i have lost 45 pounds since diagnosed im on a low carb diet and hoping to be off medicine in another 6 months,metformin has made me less hungry for sure i wish you the best:)

hughsbayou 2012-02-14 10:40:51 -0600 Report

I'm a low level T2 and they started me on Metformin back in april. It definitely caused gastro distress. At first it was all I had to work with so I endured it, but by august I had some real serious stomach and intestinal pain and problems. In the meantime I discovered that diabetes makes us thiamine deficient, up to 70%. Thiamine (B-1) is essential to the cells using the glucose they receive. No thiamine, no energy. The reason we are thiamine deficient is all the urination caused by diabetes. Then I discovered Benfotiamine, which is a synthetic B-1 fat soluble subsitute. I started taking it and was soon able to drop the Met. Now all I do is a low carb diet and a strong B vitamin formula, fish oil, Alpha Lipolic acid and the Benfotiamine. My BG doesn't do large swings, never goes too low and seldom very high. I also exercise on a regular basis. I feel much better and I have a lot less intestinal distress. Almost like being normal! Except I'm not, because I notice if I eat a lot of carbs and am not able to take the vitamins, my BG will go much higher than a normal person's would. So it alleviates but doesn't cure. (a normal person's BG won't go above 125 no matter what they eat)

dietcherry 2012-02-14 22:02:21 -0600 Report

I really need to get some of that Benfotiamine; Ive seen several others mention it here. Thanks for sharing!!

Amy Tenderich
Amy Tenderich 2012-02-13 13:44:11 -0600 Report

We wrote a whole article about Type 1's taking metformin here:


Hopefully this will be useful info + testimonials from other patients on both insulin and metformin.


dietcherry 2012-02-13 14:49:13 -0600 Report

Holy Smokes Amy! I learned more in your article and reader responses then all the googling I did about this subject for days!
I think this revealed the source of my somewhat excessive need for insulin over the last 5-6 years and am thrilled to know that after menopause, the need recedes.
Thank you for sharing with all of us; I hope others seeking answers for the same questions will find them here :)

GaryFB 2012-02-12 21:48:01 -0600 Report

I have been on Metformin for maybe 2 yrs, and have continued it while on my insulin pump with CGM. A good number of lows, but I keep a few nature valley granola bars around and I am ok. Not that big of an inconvenience. Good on the A1c at 4.9. I see every day as another triumph.

dietcherry 2012-02-13 20:20:01 -0600 Report

Excellent A1c! You should be very proud of yourself!!

GaryFB 2012-02-13 20:27:50 -0600 Report

The funny part is that my diabetes educator is concerned that it dropped from 8.3 a year ago! I laughed, saying the program is too effective.

berrykins0 2012-02-10 05:40:05 -0600 Report

i been taking metforin for 3 yrs have no side effects from it i never experience any lows from it either keeps my blood sugars under con trol along with diet and exerise for me.

Jan8 2012-02-11 09:46:03 -0600 Report

Metformin made me feel good again for 1 yr. Then since on insulin I have never felt well.

sonas 2012-02-10 06:20:42 -0600 Report

Tina i was on MET for 4 years but found the doseage was very rough on my stomach
did not like it at all
but i know others can tolerate higher doses than i was on
Horses for courses!

berrykins0 2012-02-10 14:22:23 -0600 Report

sorry to hear you had problems with it. i was on 1000 millagrams for 1 yr which means 2 tablets then she put me back to taking 1 tablet . i have been on 1 tablet for almost 2 yrs now. 1 tablet is enough enough for me now . i'm not on any other kinds of meds for diabetes at all or insulin either. i never have been on any other meds for diabetes or insulin, guess i'm kinda lucky.

Graylin Bee
Graylin Bee 2012-02-10 04:25:20 -0600 Report

Yogurt helped me during the adjustment period. Yogurt every morning saved on toliet paper. It seems the appettite suppression ended way to soon for my needs.
Hope the benefits outweigh the side effects in your case.

dietcherry 2012-02-10 08:45:45 -0600 Report

Oooh wish I would have thought of that last week!! lol It seems to be gone now—YAY! Thanks Graylin for your support!

Lisa07 2012-02-09 21:14:00 -0600 Report

Hi Dietcherry: I've been taking metformin 2xday for almost 10yrs. The only thing i don't like is upset my stomach. I was told from doctor this meds can make me loose some weight in a long run. I know you dont want to loose weight, lucky you LOL some people do. Well in my opinion, if you can tolerate the bathrm trip than is ok. FYI metformin is great T2 meds, cause it doesnt make me have low blood sugar. Btw i heard some study that Metformins can also help use for cancer patients thats good news. I hope all is well with you! You have a good one. Goodluck!!

dietcherry 2012-02-09 21:45:55 -0600 Report

Lisa I so appreciate you taking your time to let me know how Met is working for you. And isnt it great that it also helps those with cancer! I am well Lisa and I hope that you are too—thanks again!!

Armourer 2012-02-09 20:03:58 -0600 Report

I took metformin for many years then I saw a endo doc and he immediately had me quit cause the metformin made notice in by blood work that the red flag of .8 was not noticed by my former doc and was now 1.4 and had started kidney & liver disease. Stopped the metformin and switched to insulin and is six months things had started to reverse. I'm extremely insulin resistant, and for me metformin isn't the anwer, FOR ME. Good luck.

dietcherry 2012-02-09 21:42:33 -0600 Report

Hello Armourer! Its been awhile—hope you are well!
Thanks for stopping by and sharing your experience with me and Im happy to hear that your situation reversed! :)

'Second Chance'
'Second Chance' 2012-02-09 13:26:51 -0600 Report

Hi dietcherry, I take Metformin, 500mgs, 2x a day…along with my diet, it helps me control my BS!!!!! My prayers is that the change that your Dr. has made for you, will be to your advantage!!!! Hang in there my dear friend!!

edvel54 2012-02-09 11:13:37 -0600 Report

For many years I was on either avandia or Actos along with Metformin & 33 units of Lantus insulin. My AC1 was always below 6.0.
I was taken off Avandia & Actos because they were said to cause heart problems, I was put on Janumet (januvia & metformin) & insulin. Then I had some negative kidney test & was put on Januvia no metformin. I have increased my insulin use by double I take 70 units I have found especially at night my BS drops low..
Doctor suggested I split what I was taking. I now take 40 units in the morning and 30 at night,,,seems to be working better

dietcherry 2012-02-09 12:08:57 -0600 Report

Hello Velaine! How much Met do you take daily? So are you saying you needed to increase your insulin amount by double after quitting the Met and starting the Januvia? Does Januvia work differently than Met? Thanks!

edvel54 2012-02-09 13:54:36 -0600 Report

I take one januvia daily…it works but I use more insulin than when I was on metformin. I was taking 1000mg 2 daily. I am not sure if the side effects for metformin was worth it. Dr. said that the metformin was a major contributor for kidney disease..

margokittycat 2012-02-08 23:52:58 -0600 Report

Dietcherry, Metformin can supress your appetite, in some people it will go away as their body's adjust to the medication and in other's it just stays around. I to have been diabetic for 32 years and I can only take the Humulin Regular insulin. I am allergic to all lond lasting insulins and believe me when a new one comes out I always try it. They all do the same things my BS go sky high no matter what the dosage of that insulin is. I hate taking 4-8 shots a day but what else can you do.

Your question about the Metformin is yes that is normal and yes it may go away. I have been a Pharmacy Tech nician for 12 years and have had a lot of people ask that question.

Good Luck My Friend!

dietcherry 2012-02-09 09:50:06 -0600 Report

Hey Margo! Thanks for joining us! I think the stomach distress has pretty much left now but I still only have an appetite occasionally. I just started on it 2 Mondays ago so its still early days.
Ive seen a few posts about insulin allergies lately; if I may ask, what kinds of symptoms does that bring? I wondering if that could be a possibility for me—Im not ruling anything out. I have many many allergies so…

Thanks for the luck!!

margokittycat 2012-02-09 15:44:51 -0600 Report

Dietcherry, I can only tell you that with mine they had me on a 70/30 mixture and then one that was 50/50. They could not figurre out why no matter what does they put me on my BS were always out of control. The endo finally ran some test and did something's that made them discover I was allergic or immune to the long lasting insulins. I was two years into the diagnosis and they had me on more insulin than anyone had ever heard of a diabetic at 10-12 years old had ever been on.

You are welcome for the luck and you are in my prayers for a safe journey through all this and a well outcome with the stomach distress and appetite coming back.

dietcherry 2012-02-09 16:19:46 -0600 Report

Thanks for answering my question; it doesnt sound like Im allergic. And thanks for the prayers always!!!

margokittycat 2012-02-09 18:48:16 -0600 Report

I am glad I could help in anyway. You are always welcome for the prayers, all my friends on DC whom I consider family as well are always in my prayers. Have A Great Night!!!!!!

MoeGig 2012-02-08 18:40:45 -0600 Report

Just read ahead a little…70 units of insulin. Definitely sounds excessive and if its mostly Lantus or the other slow acting, that's got to be the reason your having these lows. You've got to change your A1c target to 6's. A blood glucose between 80 and 180 is fine as long as you correct something higher with a (very) little humalog. This gets you a 6.5.

Set apart
Set apart 2012-02-09 05:48:40 -0600 Report

When I met with my Endo and state that I wanted to get my A1c below 6.0 I am at 6.6 now dr. Said that he'd like me to stay in the 6s since below that you do put yourself at risk for dangerous lows! Not sure!

dietcherry 2012-02-08 19:58:04 -0600 Report

I have tried every insulin and always return to the Humulin N and R; they seem to suit me the best.
Moe Im really hoping that the Metformin is going to be the answer to my prayers. Ive been living in a Diabetic No Mans Land for too long.

When I started the Met, my Endo lowered me to 36 insulin units daily and this may even be too much because the Met is killing my appetite! lol I want to be able to eat like a normal person so Im hoping this is only temporary. :)

KellyJo76 2012-02-09 11:25:33 -0600 Report

I was diagnosed as LADA and my Endo started me on Metformin to make my honeymoon phase last as long as possible. I had no appetite either! It seems like it took a couple of months before adjusting to it. Hopefully, you are almost there because it sounds like its helping with the resistance.

dietcherry 2012-02-09 12:47:10 -0600 Report

Hi Kelly! Its either helping with the resistance or its causing me to eat so little that my blood sugar is staying low. Im trying it for 3 months and then in April my Endo will decide if I do in fact have resistance. Seems there would be another way to determine that but being T1 and not T2 I guess a glucose tolerance test wouldnt work. ??
How long have you been in your honeymoon phase? So the Met allows your body to produce/use less insulin?

KellyJo76 2012-02-09 13:40:57 -0600 Report

Oh no… this was years ago when Metformin was a fairly new drug. My honeymoon phase did last for an entire year though and I am pretty sure it was the Metformin that helped. My endo told me that it increases insulin sensitivity so your body better uses the insulin in your system whether you are producing it or injecting it. So, yes… since you are more sensitive to it, you need less. Also, on just about every website that discusses Metformin, it is known to help contribute to weight loss… probably because of the nausea and other unpleasant side effects… ;-) I don't remember having any other problems other than I just wasn't hungry for the first couple of months that I was on it.

dietcherry 2012-02-09 15:34:04 -0600 Report

So even if you are not technically resistant, it will still increase sensitivity? Im sorry to ask so many questions Kelly, Im just wanting a clear picture for myself and others who may seek answers here :)
Im glad you didnt have any other side effects from it; overall it appears to be a very good and helpful med for most!

Richard157 2012-02-08 18:33:20 -0600 Report

I was diagnosed in 1945, when I was 6. I was never more than 5 pounds above my ideal weight until the 1990s, when I started using modern day insulins. I gained weight and was diagnosed in 1998 with insulin resistance. Avandia was the medication prescribed at that time. I reduced my carb intake to 130 g per day and increased my exercise. Gradually, I lost weight. Avandia was found to cause heart problems with many users and my doctor refused to renew my prescription. After 13 years with Avandia and good control, it was hard to give it up. Now I am using Metformin, for almost a year now. Metformin ER, 1000 mg morning and evening. I did not have any unpleasant side effects with Met. It has decreased my appetite, and I have lost an additional 18 pounds. Now I am only 5 pounds above my ideal weight. I was losing weight too fast to suit me and, a few months ago, decided to increase my carb intake to compensate. Then my carb intake was 150-160 g per day, and my weight loss slowed down. My weight loss has stabilized, and I am using an average of 33 units of Humalog per day with a pump. My A1c's have been below 6.0 for almost 10 years.

My only problem with Met is that my BG's are less stable than with Avandia. I have more lows and highs, especially lows. I don't like falling into the low 50s and the 40s several times each week, but I am always able to take care of myself with the lows. I have not needed help with a low since July, 2007. I have not been able to avoid the lows, but am still working on it.

Did you know that a type 1 diabetic with insulin resistance, and taking a type 2 med, is called a "double diabetic"? You can Google that term and read much about it.

dietcherry 2012-02-08 19:41:38 -0600 Report

Hey Richard! Thanks for chiming in! I did not know you were on Metformin!! May I ask you what your insulin dose was prior to starting Avandia and then during use? Also what is your daily insulin dose now?
I feel really good on the Met despite the stomach issues and today Ive been fine and my Endo said if I was one of the lucky ones, symptoms would subside during the first 2 weeks. Keeping fingers crossed!
The double diabetes: is this to say that if I hadnt developed T1 as a child, I still would have been at risk for T2 later on?? Was D my destiny??

Richard157 2012-02-08 20:38:04 -0600 Report

I don't remember my insulin dosages before prior to Avandia, that was almost 15 years ago. While on Avandia my total daily dosage (TDD) was 34 units. Now it is 33-34 units per day. So Avandia and Met are about equal, for me, in helping with IR.

If you have the T2 gene, then you are predisposed to have T2. Some people with the gene never become T2 though. Something has to trigger it, and it is usually overweight that does so. About 20% of T2 diabetics are not overweight when they are diagnosed. Most overweight people in the US never become diabetics, because they do not have the T2 gene. My sister needs to lose about 90 pounds. She has been that way for meny years. She obviously does not have the gene. We have many relatives aho are T2. I think I must have the T2 gene since I was not terribly overweight, but still developed insulin resistance.

Yes, I think you have the gene, and that means you would have been at risk for T2, even if you never had T1. You and I, with T1, do not produce any of our own insulin. Just because we now have IR does not make us T2. We have T1 and we have a T2 characteristic, but we are not T2. We are double diabetics.

dietcherry 2012-02-08 21:15:31 -0600 Report

Thanks Richard. We cant trace any T2s OR T1s in the family, either side. My Grandmother had medication-induced high blood sugar at 95 years old, which I thought for a long time was T2, until a relative set me straight. It went away when they discontinued the med.

I guess the genes leap-frogged a few generations. Anyway, I wonder how many of us double diabetics there are? Any statistics?

Richard157 2012-02-09 12:56:36 -0600 Report

An estimated 70% of T1 diabetics do not have any relatives with T1. Neither you nor I did. T2's are much more apt to become diabetics via gentic transmission. I had mumps ad chickenpox when I was 6, in 1945. I was very ill and started showing the symptoms of diabetes while I was recovering. A few days after my 6'th birthday I was diagnosed. Ilnesses like that can cause internal damage, and the pancreas can fail or burn out.

I don't have any statistics on the prevalence of double diabetes. I found one source that says that if the pancreas of a T2 produces less and less insulin, and they become insulin dependent, then they are also double diabetics. They still take a T2 med, because they still have IR. That is exactly like me, but I was T1 first, and then had IR with Met. I have a few online friends who were T2 first with Met, and then had pancreas failure and insulin dependence.

dietcherry 2012-02-09 13:25:45 -0600 Report

Richard I never knew that. I guess it could be interpreted another way too: because T1 is somewhat uncommon, by the time a person is diagnosed, anyone else in their bloodline also T1 may well have passed on.
I didnt have any illness to tie mine to; it just sprung forth.
Here I thought we double diabetics were something special but apparently not! lol ;)

Richard157 2012-02-09 13:44:47 -0600 Report

I am sorry I made so many grammatical errors in my post. I was in a hurry, but now I have edited, and cleaned up the mess. Lol!

MoeGig 2012-02-08 18:33:08 -0600 Report

Hi Diet Cherry: For the second time in 2 months, I woke up with a roomful of EMT's giving me an IV of glucose. Going to see my endo next week and will suggest this to him. I think, however, you're aiming too low on the A1c. I've been averaging 6.5 which is plenty good enough. When I use to aim for the 5's, it's like flying a jet trying to avoid buildings in order to avoid radar…if you miss, you crash. I've decided to set my alarm for 2am each night to do a bg check. Catching it before it submarines is the most important thing. The other thing I do is that I don't take any humalog/novalog at night. Lantus give you a more gentle low. I did screw up last week by misjudging this again which caused my wife to call 911. Not fun (and scary…you might "wake up dead" as my brother once said).

dietcherry 2012-02-08 19:34:38 -0600 Report

Hi Moe! Im sorry you experience it too! I would be happy to score a higher A1c and as we all know, the A1c is merely a picture of the average blood sugar over the last 2-3 months, not an accurate account of how well in control a person actually is. I have my share of highs too. There is something going on with me and my Endo and I are trying to get to the bottom of it.
That is actually called "dead in bed" syndrome and it scares the bejesus out of me!!!!

dietcherry 2012-02-08 16:49:16 -0600 Report

Anyone on Metformin, I urge you to click the link below and it will take you to Kates discussion, where she copied the article as a reply!

J Kate
J Kate 2012-02-08 16:11:31 -0600 Report

Here is an interesting study on metformin and lactic acidosis: http://www.diabeticconnect.com/news-articles/...

nzingha 2012-02-08 04:15:24 -0600 Report

hi diet cherry..wow ur situation sounds so complex.. i thought mine was…i too believe i am allergic to the insulin. i have developed this thing called cushings disease or syndrone.. they r still testing, but i've found once i dont touch the carbs, just fruits, vegs, meats, nuts… i am fine… i get very good readings.. but my body craves the carbs and every now and then i have to get some.. plus taking insulin..u also need some carbs. i find i get hungry a lot when i dont have any carbs …

dietcherry 2012-02-08 12:26:54 -0600 Report

I remember your discussion about Cushings; I hope you will get answers soon. We all need carbs in our diet; talk to your Dr about the reason they are causing you to spike so much. You might need more insulin to keep you well-controlled.

dietcherry 2012-02-07 23:46:39 -0600 Report

Wow had another low tonight. Lasted a really long time too. Does this mean the Met is working at increasing my insulin sensitivity or is it only preventing my liver from stepping in and giving me some glucose? Both??

Is the Met strongest when first taken and then slowly dissipates over time or is it truly released evenly?

This is new territory for me and my Endo didnt really elaborate on what I could expect. And here comes the stomach-churning again. Yuck.

Looks like I may have to cut back on my insulin dose even more. And here I was thrilled to only be taking 36 units a day now!

rij061258 2012-02-08 00:45:35 -0600 Report

It is suppose to help your body use insulin more efficently and help keep your liver from storing excess sugar, at least that is what my dr told me. But then he also told me that the Met alone would not make me go low. Have proved him wrong there. Seems my body likes to do what is unexpected.

dietcherry 2012-02-08 12:34:29 -0600 Report

Hello! Yes I know its designed to do both; in my case, we are attempting to determine if I am truly insulin-resistant. If I am, then its working in increasing my insulin sensitivity and NOT just keeping my liver from releasing glucose.

What did your Dr say when you told him you were going too low on Met?

rij061258 2012-02-07 22:44:25 -0600 Report

I just started taking Met 2 weeks ago. Started at 500mgs once a day and was suppose to go to 500mg twice a day. It started lowering my #'s by day 3 of the first weekl, thought things were going to finally even out then went low the first saturday and then again on sunday. Wasn't sure I wanted to add the second pill but then at the beginning of the second week, I started running a bit high. So decided to try just taking half a pill in the am and the whole one in the pm. First 2 or 3 days things was good then, I started seeing my number drop even lower. Was seeing normal non-d #'s, then came the weekend and I was going below 80 again. Had 3 low episodes sunday and if I hadn't woke up and eaten something, I probably would have woke up really low. I ate 2 ding dongs and am bg was only 102. I forgot to mention I have decreased the amt of met I was taking over the weekend. sunday I only took about 375 mg over the course of the day. I'm starting to be afraid of taking any of the met at all, when such low mg is causing me to go low. My dr had told me, I wouldn't go low even if I wasn't eating as I should. It is still hard for me to eat more than twice a day, even more so when taking the Met. Haven't taken any today and my #'s haven't been all that bad. Guess I will have to play around with the doses to see what I can handle taking. Or I may just have to call my dr and tell him the problem I'm having. Hope this helps you some dietcherry. BTW, the Met is the only D med I'm on. Did find online that betablocker drugs can when taken with Met can cause lows.

dietcherry 2012-02-07 23:38:15 -0600 Report

Please click on the link jigsaw posted right below us. It said if you are not using any other med, insulin or oral, that you wouldnt go low on Met. Well so much for that huh?
Sounds as if you could possibly manage without meds; please be careful! Lows are nothing to mess with :(

annesmith 2012-02-07 22:09:14 -0600 Report

I was originally diagnosed severe severe brittle type 2, and they tried me on Metformin, and my pancreas rejected it altogether. Then, on top of it all, it greatly cut off my appetite. I have no idea why, but I simply cannot take it. They also found that I am allergic to the natural sugar my pancreas produces in itself. I am not helping you at all…I'm sorry..ha. I just wish I could find someone that can relate more to how I absolutely can't take Metformin. They also said I am allergic to the Metformin itself. ANNE

dietcherry 2012-02-07 23:31:20 -0600 Report

What were the rejection symptoms? Isnt there another med you can use like Januvia? Sorry I really only know them by name, not what they do or how they work :)

jayabee52 2012-02-07 18:48:38 -0600 Report

Tom spoke for me when he recommended you to be careful of your kidneys.
I believe Met had a lot to do with mine going south and me needing dialysis for a while, and me perhaps needing it again in the very near future.

dietcherry 2012-02-07 19:18:07 -0600 Report

Thanks James! Can you please be more specific about the risk to the kidneys or did you have a rare reaction to Met?

jayabee52 2012-02-07 19:37:04 -0600 Report

all I can say for sure is that I was taken off met as soon as my kidneys quit. Nobody said anything to me about what went wrong except that I had a kidney infection. Don't know if you remember me telling the account of me being on my bedroom floor for something like 5 days before that? I have been reading that met by itself will do it, and then I've read that met together with MRI contrast dyes will do it too. I did have some MRI with contrasts done a little before that.

Nick1962 2012-02-08 10:44:58 -0600 Report

Met can cause lactic acidosis, and thus kidney disease, but it's claimed that the patient is usually at high risk or comprimised to begin with. Phenformin was withdrawn for this reason.

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