Studies show Niacin in doses of 1000mg/day do not increase insulin resistence.

By Caroltoo Latest Reply 2012-01-14 17:14:32 -0600
Started 2012-01-14 16:36:31 -0600

Thanks for the link James, I've been looking this morning to see where the concern between Niacin and diabetes came from. There are two studies quoted below which state that in the dose usually prescribed for heart patients, 1,000 mg, Niacin does not result in increased insulin resistence. In fact, they say the study indicates IMPROVED control of BG.

In dose of 2,500 mg. in diabetics who have poor BG control already, it has shown some negative effects. This is good to know to avoid the higher doses, but let's not through the baby out with the bathwater on this since many of us have or will have heart related issues.

"Multiple studies were conducted to study effects of nicotinic acid on exacerbating insulin resistance. One retrospective study suggested that the use of moderate doses of extended release nicotinic acid (average, 1000 mg/d) in reasonably controlled diabetics was associated with improved glycemic control with HbA1c levels decreased by 0.5% ± 0.3% due to aggressive hypoglycemic therapy; as most of these patients had their insulin or oral diabetes regimen intensified [6]. Another retrospective study using unmodified niacin concluded similar results [7]."

4 replies

jayabee52 2012-01-14 16:52:04 -0600 Report

You're welcome Carol and Thanks for the new discussion. I looked a bit and found nothing to contradict the statement about niacin exacerbting insulin resistance, but I didn't look all that hard. Do you have sources for those quotes, or better yet, links?

For me it is merely academic as I don't use Niacin, but my ex did because she had high cholesterol and had trouble with statins.

Caroltoo 2012-01-14 17:14:32 -0600 Report

The source of the quote is your link…it's about 3-4 paragraphs in and lifted verbatim.

It is a concern to me, because my doctor just suggested I use Niacin 1,000 mg to bring down my LDL (the only one that is high). So, I shall continue to take it. She incidentally, did caution me not to take more that 1,000 mg., so must have read something similar.

hillwalker 2012-01-14 16:42:35 -0600 Report

yeah the article i had read stated only seen in high doses such as used to treat cholesterol but we all need to look at all aspects

Caroltoo 2012-01-14 16:49:00 -0600 Report

I picked up on this in concern because my doctor had just suggested I use 1,000 mg. of niacin/day to bring down my LDL (all the others are ok), but I maintain my BG by diet and exercise, so needed to be sure that Niacin would not affect that choice.