red flower lady
By red flower lady Latest Reply 2012-02-15 10:22:57 -0600
Started 2012-01-11 21:32:30 -0600

I just read an article about using a diabetic medicine to lose weight. It is called exenatide (Byetta, Bydureon) according to a Danish researchers report. I found it on www.everydayhealth.com Jan10,2012. This medicine is used for Type 2 diabetes and is injectable, but it is not an insulin. Weight loss and lower cholesterol levels are side effects of this drug, and in diabetics, can lower blood pressure.

The drug is being studied to treat obesity in non diabetics. In the study it said that non diabetics lost more weight, but the drug shouldn't be used alone to lose weight.

I was wondering if anyone has used this drug and if they lost weight. I am a type 1 and have always used insulin, so I have never heard of this drug.

Thanks for any info as I'm all for weight loss.

Tags: weight loss

22 replies

Lizardfan 2012-02-09 22:15:59 -0600 Report

I have used Byetta since 2006 with excellent results. I have a endo appt. next week to start on the new Bydureon, the once weekly injection. It is a more concentrated Byetta and has shown good results in the drug trials. It is available in pharmacies on Friday, Feb. 17th.

Patients reported nausea with this version of Byetta as well. My doctor has had me take Compazine whenever I get the nausea and that takes care of it. I can't eat greasy food, spicy etc. or *Lizzie* will get me every time.

I am very excited to be trying this drug, sure beats injecting twice every day!

red flower lady
red flower lady 2012-02-11 12:03:57 -0600 Report

Good luck with it.

Lizardfan 2012-02-12 15:07:53 -0600 Report

Thank you. I do expect to have some nausea when starting the medication. I had lots of nausea when I started on Byetta, I just worked thru it and stuck with it!

Anonymous 2012-02-12 15:06:52 -0600 Report

Lizzie is the name I use for Byetta 10, it is derived from a synthetic form of Lizard saliva. Hence, Lizzie! Sorry if you were confused. I won't know if my insurance will allow me to use Bydureon until Friday when it is available for purchase in the Pharmacy.

GabbyPA 2012-02-13 09:34:29 -0600 Report

A lot of our drugs come from, shall I say, less than savory sources. But if it works and we have better lives because of it, then there you go. Besides, who doesn't need a little lizard kiss now and then? LOL

Lizardfan 2012-02-13 16:17:22 -0600 Report

It is the SYNTHETIC form of the saliva, not real saliva. Doctor's studying insulin like hormones etc. in nature discovered that the gila monster's saliva contained an enzyme that slows the digestion of their food. They developed the drug exenatide by these methods. As Gabby says, lots of drugs come from this kind of research. The drug slows the food absorption and I don't get the blood sugar spike, at least that is how it works for me.

jayabee52 2012-02-13 19:13:48 -0600 Report

I think I read about it being fake version of Gila monster saliva. That's why Lizzie and lizard spit threw me off track. And yes, I know Gila monsters are in the lizard family.

red flower lady
red flower lady 2012-02-14 11:58:22 -0600 Report

Still gross!! And not having a fondness for reptiles, this freaks me out. Glad that drug isn't an option for me. I'm sure my meds have something else that is gross in them, but I am not aware of it:)

jayabee52 2012-02-14 13:06:09 -0600 Report

it's not REALLY lizard spit or Gila monster saliva, but a synthetic verison of the latter. Why do you say that Byetta is not an option for you?

red flower lady
red flower lady 2012-02-15 00:25:23 -0600 Report

Oh, that's great. I hope it helps those who use it. I am not a type 2, and that drug is for them. I have always been a type 1 insulin dependent since an early age.

GabbyPA 2012-02-15 09:29:20 -0600 Report

Natural insulin for type 1's used to be from cows or pigs. Is that all that different? Now they use synthetic insulin and there are many type 1's who would rather have the natural insulin because they have less reactions to it.

red flower lady
red flower lady 2012-02-15 10:22:57 -0600 Report

For me yes, as insulin isn't a choice and Byetta is. Also, cows and pigs don't freak me out. Now if I had no choice and Byetta was all there was, then I would take it.

MrsCDogg 2012-01-15 07:47:04 -0600 Report

I used Byetta for several months. It did wonderful helping to control my blood sugar. However, I discovered the reason it helps you lose weight. Nothing stays in your body long! I was sick from the moment I started it until I stopped taking it. I couldn't stay out of the bathroom. It is the same affect that I get from metformin. Massive gas and diahrrhea. It was awful. There were even days when I'd miss work. I refuse to ever take it again.

red flower lady
red flower lady 2012-01-15 17:03:33 -0600 Report

Thanks for the info with your experience with Byetta, I don't want to be doing the whole bathroom dance either. I never did Metformin so I'll take your word. Thankfully, insulin doesn't do that, so thats a plus.

jayabee52 2012-01-12 05:13:48 -0600 Report

Howdy Darlene!
I do not use any medications to lower my Blood Glucose (BG) levels at the moment, but I do keep up with things happening on DC, and so I searched for "byetta" and got this list of discussions which mentions byetta. See it here ~ http://www.diabeticconnect.com/discussions?qu... . i

There is also a product review for Byetta (75 replies) here ~ http://www.diabeticconnect.com/product-review...

Hopefully through these you may be able to find this useful.

And BTW, are you aware of the obesity connect site? If you are not on it, perhaps you might want to give them a look-see.

To your better health


red flower lady
red flower lady 2012-01-12 15:02:40 -0600 Report

Thanks james for the info link. I only want to lose a few pounds and don't need the obesity site at all, but I'm glad it is there for those who are in need. I may go there to see what the latest news is as I'm sure that site probably has info about my previous post. Doing insulin puts weight on and I would like to stay on top of it as it is hard to get it off.

GabbyPA 2012-01-13 01:01:08 -0600 Report

I think if you read the side effects you will see that the reason you loose weight with it is often because you experience nausea and diarrhea. Neither of which are the way I would want to loose weight. I don't know if once you get used to the med and it stops those effects if it is still good for weight loss.

Lizardfan 2012-02-12 15:26:01 -0600 Report

Great post Gabby. I did get used to the nausea after I had been on Byetta for awhile. It still bothers me sometimes when I start a new pen, not sure why that is! Also, you feel full and don't want to eat as much, that curbs your appetite too. It is like any other thing you need to do to lose weight…you have to work at it if you want to lose! It is not just automatic!

jayabee52 2012-01-12 21:12:34 -0600 Report

I know that myself for I had been on insulin from Nov 2006 to Feb 2011. Now I am off of insulin, had success with an experemental eating plan, and kept my Blood Glucose close to "Normal" and my last A1c was 5.5. As a bonus I lost about 50 lbs since Feb 2011.

Hadn't had much success losing the weight before that, and have been "husky" or "stout" most of my life. Now I am doing well keeping the weight off.

Next Discussion: Messing up bad lately »