Alpha Lipoic Acid as a Tx for Diabetic Neuropathy

By Caroltoo Latest Reply 2012-01-30 18:28:17 -0600
Started 2011-12-19 14:32:17 -0600

Alpha Lipoic Acid is used for treatment of Diabetic Neuropathy as mentioned in this study done at the University of Maryland. It also describes Alpha Lipoic's action in repairing cells damaged by diabetes. Dosage listed here is small. In clinical Alzheimer's studies, they use 600 units morning and evening without side effects except for the need to supplement your biotin because the ALA does deplete the biotin in your body.

After diagnosis 8 years ago, I used 600 mg of Alpha Lipoic Acid morning and evening and also take 5,000 mcg of Biotin with the morning dose for several years. I had d.n. in my left heel (felt like I was walking on a pebble…kept checking to see if I had a stone in my shoe) when I was first diagnosed. In a few months, the sense diminished, then one day I realized it was gone. I've not had any other occurrences since then. For the last 3 years I have decreased my dosage to the ALA and Biotin to the morning dose only…no evening ALA.

22 replies

digitaldoorbell 2011-12-20 22:22:01 -0600 Report

You are very fortunate. ALA did not work for me. Actually, the R-Alpha is better, but I still have neuropathy.

dietcherry 2011-12-20 12:24:30 -0600 Report

As a precaution, those with hypothyroidism should be particularly careful consuming an ALA supplement, as it can counteract the effects of thyroid medication.…/alpha-lipoic-...;

lori lorchid
lori lorchid 2011-12-20 15:17:38 -0600 Report

I take 600 mg a day if I'm having an unbearable amount of pain I'll take 100-200 more mg and I'm telling you It's been a God send!!

Young1s 2011-12-19 23:13:19 -0600 Report

Very interesting Carol. I've been noticing a lot of talk about neuropathy in discussions lately. This has me concerned because I've been experiencing some pain in my knees when I stand and take a few steps. This is after sitting down for a long stretch at a time. Generally, I tend to sit with my legs folded underneath me, so my thinking is that I am just getting too old to sit like that anymore.

However, with all of the talk that has been going on, I guess I'm wondering is this the first sign of neuropathy. I do try to get out of the house for walks but I will admit that I had been slacking off. To make up for that though, I have been doing a modified version of step aerobics. Needless to say I have yet another thing to add to my list of concerns for my next doctor visit.

jayabee52 2011-12-20 06:21:58 -0600 Report

It COULD perhaps manifest in the way you describe I guess, my first clue I had the start of DN was "electic shocks" in my legs which would make them jump mostly at night when I was settling down for the night.

Caroltoo 2011-12-19 15:38:18 -0600 Report

ALA is the acronym for Alpha Lipoic Acid which is very helpful, but also for Alpha Linolenic Acid which is not.

Alpha Linolenic is a plant based source of Omega 6 which we already have a disproportionate amount of in our corn and wheat based diets. I've seen comments that is contraindicated for diabetics. Unfortunately, I had taken a bottle and had some nasty side effects before the company decided to label the Alpha Linolenic with a warning that diabetics should not use it. I returned the second bottle and regained my health after a few months.

jayabee52 2011-12-19 15:29:17 -0600 Report

I have used ALA for about 6 mos now. Just recently started pairing it with Biotin (5000 mcg) I noted a recuction in my level of pain — i think (level of pain is rather subjective)

Gotta find another source of the ALA because I am almost out of it. I worked my way up from 200 to 600. I am planning to work my way up to 1800 and see if that helps more.

JerryB6768 2011-12-20 14:52:49 -0600 Report

You might want to try the solubilized product that is more bioavailable and you won't have to go to 1800. The product is called Thiogel and they have a free trial offer.

jayabee52 2011-12-20 15:17:35 -0600 Report

does one have to get an Rx to use it? Who manufactures it?

I understand in Germany they administer it via injection which I am told was most effective in relieving neuropathy pain.

JerryB6768 2011-12-20 20:15:38 -0600 Report

It's still a dietary supplement. It's made by Ethical Alternative Products. You can get a trial bottle at Intravenous ALA is the most effective, but you can get good blood levels with the solubilized ALA versus the powder-based products.

Mickey/CCHT 2011-12-19 15:19:05 -0600 Report

I firmly believe in ALA. I have noticed that my neuropathy is not as bad as it once was. I also use it as a diet aid. I take 250mg with each meal.

reneeramaekers 2011-12-19 19:14:20 -0600 Report

I had some but gave it to my mom because of the Alzheimers ( my grandmother and great grsndmorher both had) but cone to think of it my neuropathy has gotten worse since I've stopped !!! Going to get some more tomorrow !!'

chayogarza 2012-01-30 13:56:54 -0600 Report

help me understand.ALA. I was wondering how does it work would it repair damage already done due to neuropathy?or just the pain.i have neurapathy and am very scared . i have been keeping my readings below 100 . to avoid any future damage.

Caroltoo 2012-01-30 14:15:37 -0600 Report

What I have read indicates that it helps the cellular structure damaged by too high blood glucose levels repair themselves. Nerves, as I understand it, are made up of cells that repair most slowly, if at all. I believe it helps prevent more damage and I have had improvement myself, but mine was very mild to begin with.

The other thing ALA does is help keep your BG down which also helps prevent further damage. To me that's a win-win: lower BG so less harm and help repairing at least some of what has happened.