Insulin release, use, &/or Insulin resistance

By Zolar1 Latest Reply 2011-05-14 18:41:26 -0500
Started 2011-05-03 13:53:30 -0500

How many of you have been told or discovered that you have a defective 1st phase insulin release?

I discovered that my 1st phase insulin release (the insulin that is released during the 1st 2 hours after eating) is defective or nearly non existent. I say this because if I shoot insulin and sit on my butt or sleep, my blood sugars aren't affected much at all, but if I move around, my blood sugars can be quite normal. Much depends on what I eat and what kind of activity I do.
If I eat an all meat meal, don't shoot insulin, and sit on my butt, my blood sugars are quite manageable.

I also discovered that my 2nd phase insulin release is defective and I may also have some insulin resistance (due to insulin related weight gain).

So, how many of you out there have either been told that you have the same problems I do or what did your doctor tell you what the cause of your diabetes was? What did the doctor suggest you do to help control the problem?

A blanket term of 'insulin resistance' is not a real diagnosis unless they did C-Peptide tests and insulin levels tests. Such a diagnosis without actual tests or a history of insulin use vs. blood sugar tests means your doctor is just being lazy.

Do you know your ISF? That stands for Insulin Sensitivity Factor. A ratio of how much insulin vs the carbs you eat. This too can vary widely from meal to meal and time of day. If you are familiar with geometry, you generally have 3 axis - x,y,z. Each letter would correspond to diet (x), exercise (y), and insulin production/use (z). Goal is to have your diabetes at these coordinates: 1,1,1 or any equal ratio such as 5,5,5 or 10,10,10, etc. I could probably devise some sort of complex model to incorporate other factors if I feel froggy enough to do it.

"Controlling blood sugars with diet, exercise, and insulin/medications is like walking a tight rope with squirmy kids on your shoulders"

4 replies

Zolar1 2011-05-14 18:17:32 -0500 Report

Some sites say that 1st phase insulin release can occur up to 2 hours after eating.

If my 1st phase dumped as soon as I ate, my 2nd phase would kick in and my blood sugars would be very nice.

But this is not the case. My 2nd phase usually kicks in about 2-4 hours later - sigh…

kdroberts 2011-05-04 14:56:56 -0500 Report

1st and 2nd phase insulin aren't based on time, it's based on blood sugar levels. 1st phase could last a few seconds, minutes or longer. In most non-diabetics it won't last very long at all.

The only real way to test for insulin resistance is to do a hyperinsulinemic euglycemic clamp, which is kind of overkill for a diabetic patient. C-peptide and insulin levels can be a guide but they only tell you how much insulin is being produced, not if the individual is resistant to it. Doctors can make an educated guess, but it's still just a guess. You can also estimate insulin resistance from the HDL and triglyceride ratio.

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